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Abstract：
BACKGROUND: Acute gastroenteritis (AGE) causes significant morbidity in children worldwide; however, the disease burden of children hospitalized with viral gastroenteritis in China has been rarely described. Through this study, we analyzed the data of hospitalized children with viral gastroenteritis to explore the changes in the epidemiology and clinical characteristics of viral gastroenteritis in the mainland of China.
METHODS: Data were extracted from Futang Children\'s Medical Development Research Center (FRCPD), between 2016 and 2020, across 27 hospitals in 7 regions. The demographics, geographic distribution, pathogenic examination results, complications, hospital admission date, length of hospital stays, hospitalization charges and outcomes were collected and analyzed.
RESULTS: Viral etiological agents included rotavirus (RV), adenovirus (ADV), norovirus (NV) and coxsackievirus (CV) that were detected in 25,274 (89.6%), 1,047 (3.7%), 441 (1.5%) and 83 (0.3%) cases. There was a higher prevalence of RV and NV infection among children younger than 3 years of age. RV and NV had the highest detection rates in winter, while ADV in summer. Children with viral gastroenteritis were often accompanied by other diseases, such as myocardial diseases (10.98-31.04%), upper respiratory tract diseases (1.20-20.15%), and seizures (2.41-14.51%). Among those cases, the co-infection rate with other pathogens was 6.28%, with Mycoplasma pneumoniae (M. pneumoniae), Epstein-Barr virus (EBV), and influenza virus (FLU) being the most common pathogens. The median length of stay was 5 days, and the median cost of hospitalization corresponded to587 US dollars.
CONCLUSIONS: This finding suggests that viral gastroenteritis, especially those caused by RV, is a prevalent illness among younger children. Co-infections and the presence of other diseases are common. The seasonality and regional variation of viral etiological agents highlight the need for targeted prevention and control measures. Although viral gastroenteritis rarely leads to death, it also results in a significant economic burden on healthcare systems.
METHODS: Data were extracted from Futang Children\'s Medical Development Research Center (FRCPD), between 2016 and 2020, across 27 hospitals in 7 regions. The demographics, geographic distribution, pathogenic examination results, complications, hospital admission date, length of hospital stays, hospitalization charges and outcomes were collected and analyzed.
RESULTS: Viral etiological agents included rotavirus (RV), adenovirus (ADV), norovirus (NV) and coxsackievirus (CV) that were detected in 25,274 (89.6%), 1,047 (3.7%), 441 (1.5%) and 83 (0.3%) cases. There was a higher prevalence of RV and NV infection among children younger than 3 years of age. RV and NV had the highest detection rates in winter, while ADV in summer. Children with viral gastroenteritis were often accompanied by other diseases, such as myocardial diseases (10.98-31.04%), upper respiratory tract diseases (1.20-20.15%), and seizures (2.41-14.51%). Among those cases, the co-infection rate with other pathogens was 6.28%, with Mycoplasma pneumoniae (M. pneumoniae), Epstein-Barr virus (EBV), and influenza virus (FLU) being the most common pathogens. The median length of stay was 5 days, and the median cost of hospitalization corresponded to587 US dollars.
CONCLUSIONS: This finding suggests that viral gastroenteritis, especially those caused by RV, is a prevalent illness among younger children. Co-infections and the presence of other diseases are common. The seasonality and regional variation of viral etiological agents highlight the need for targeted prevention and control measures. Although viral gastroenteritis rarely leads to death, it also results in a significant economic burden on healthcare systems.
摘要：
背景：急性胃肠炎（AGE）在全世界儿童中引起显著发病率；然而，在中国，很少描述病毒性胃肠炎住院儿童的疾病负担。通过这项研究,我们对病毒性胃肠炎住院患儿的资料进行分析,探讨中国大陆病毒性胃肠炎的流行病学和临床特征的变化.
方法：数据来自福唐儿童医学发展研究中心（FRCPD），2016年至2020年，在7个地区的27家医院中。人口统计，地理分布,致病性检查结果，并发症,入院日期,住院时间,收集并分析了住院费用和结局.
结果：病毒病原体包括轮状病毒（RV），腺病毒(ADV),诺如病毒（NV）和柯萨奇病毒（CV）在25,274（89.6％）中检测到，1,047（3.7%），441例(1.5%)和83例(0.3%)。3岁以下儿童的RV和NV感染率较高。RV和NV在冬季的检出率最高，而ADV在夏天。病毒性胃肠炎患儿常伴有其他疾病,如心肌疾病(10.98-31.04%)，上呼吸道疾病（1.20-20.15%），和缉获量（2.41-14.51%）。在这些案例中,与其他病原体的共感染率为6.28%，肺炎支原体（M.肺炎），EB病毒(EBV)流感病毒（FLU）是最常见的病原体。平均住院时间为5天,住院费用中位数为587美元。
结论：这一发现表明病毒性胃肠炎，尤其是那些由房车引起的，是年幼儿童中的一种普遍疾病。共感染和其他疾病的存在是常见的。病毒病原体的季节性和区域差异突出了有针对性的预防和控制措施的必要性。虽然病毒性胃肠炎很少导致死亡，这也给医疗保健系统带来了巨大的经济负担。
方法：数据来自福唐儿童医学发展研究中心（FRCPD），2016年至2020年，在7个地区的27家医院中。人口统计，地理分布,致病性检查结果，并发症,入院日期,住院时间,收集并分析了住院费用和结局.
结果：病毒病原体包括轮状病毒（RV），腺病毒(ADV),诺如病毒（NV）和柯萨奇病毒（CV）在25,274（89.6％）中检测到，1,047（3.7%），441例(1.5%)和83例(0.3%)。3岁以下儿童的RV和NV感染率较高。RV和NV在冬季的检出率最高，而ADV在夏天。病毒性胃肠炎患儿常伴有其他疾病,如心肌疾病(10.98-31.04%)，上呼吸道疾病（1.20-20.15%），和缉获量（2.41-14.51%）。在这些案例中,与其他病原体的共感染率为6.28%，肺炎支原体（M.肺炎），EB病毒(EBV)流感病毒（FLU）是最常见的病原体。平均住院时间为5天,住院费用中位数为587美元。
结论：这一发现表明病毒性胃肠炎，尤其是那些由房车引起的，是年幼儿童中的一种普遍疾病。共感染和其他疾病的存在是常见的。病毒病原体的季节性和区域差异突出了有针对性的预防和控制措施的必要性。虽然病毒性胃肠炎很少导致死亡，这也给医疗保健系统带来了巨大的经济负担。
