Abstract：
The present molecular investigations of Organizer phenomena show a remarkable connection to the earlier classical embryological studies that used transplantation as a method for making mechanistic models of induction. One of the most prominent of these connections is the dual gradient model for anterior-posterior and dorsal-ventral polarity. This paper will discuss some of the history of how transplantation experiments provided data that could be interpreted in terms of two gradients of biologically active materials. It will highlight how the attempts to discover the elusive Induktionsstoffen gave rise to the double gradient model of Sulo Toivonen and Lauri Saxén in the 1950s and 1960s. This paper will also document how this research into the identity of these molecules gave rise to the developmental genetics that eventually would find the molecules responsible for primary embryonic induction.
摘要：
目前对Organizer现象的分子研究表明，与早期的经典胚胎学研究有着显着的联系，这些研究将移植用作制作诱导机理模型的方法。这些连接中最突出的一个是前后和背腹侧极性的双梯度模型。本文将讨论移植实验如何提供数据的一些历史，这些数据可以根据两种生物活性材料的梯度来解释。它将重点介绍发现难以捉摸的Induktionsstoffen的尝试如何在1950年代和1960年代产生了SuloToivonen和LauriSaxen的双梯度模型。本文还将记录对这些分子身份的研究如何产生发育遗传学，最终发现负责原代胚胎诱导的分子。
