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Abstract：
OBJECTIVE: The aim of this study is a descriptive presentation of cases of acute watery diarrhoea (AWD) that were presented to Aleppo University Hospital (AUH) during the recent cholera outbreak in Syria.
METHODS: Prospective, observational, cohort study.
METHODS: A total of 1061 patients with AWD were admitted to AUH during the timeframe of 20 September 2022 to 20 October 2022. The data collection was done through a structured questionnaire. This includes comprehensive clinical observation, laboratory analyses, therapeutic interventions and holistic case evaluations.
RESULTS: The analysis has revealed notable insights: a predominant proportion of patients (58.6%) were residents from urban areas and 40.3% were residents from rural areas. Intriguingly, a diverse range of potential infection sources emerged from patient data within our hospital, including uncontrolled well water, vegetables and faecal-oral transmission through contaminated street/fast food. At discharge, most patients were in good health (79.7%), followed by moderate health (17.6%) and poor health (2.3%), with a minimal percentage dying before discharge (0.4%). The most common complications reported at admission and during hospitalisation included electrolyte imbalance (28.2%), followed by severe dehydration (16.3%). In the follow-up period, the majority of patients exhibited good health (81.0%). Older patients (>60 years) had poorer outcomes, with 8.4% having poor health and 4.2% death rate.
CONCLUSIONS: The study found results consistent with previous AWD outbreaks in developing countries like Yemen, Nigeria and Lebanon. Preventative measures like improving water sanitation and hygiene practices are essential to prevent future outbreaks and ease the strain on healthcare systems. Therefore, future studies must investigate the risk factors that increase the spread and the severity of the disease and investigate the best management method.
METHODS: Prospective, observational, cohort study.
METHODS: A total of 1061 patients with AWD were admitted to AUH during the timeframe of 20 September 2022 to 20 October 2022. The data collection was done through a structured questionnaire. This includes comprehensive clinical observation, laboratory analyses, therapeutic interventions and holistic case evaluations.
RESULTS: The analysis has revealed notable insights: a predominant proportion of patients (58.6%) were residents from urban areas and 40.3% were residents from rural areas. Intriguingly, a diverse range of potential infection sources emerged from patient data within our hospital, including uncontrolled well water, vegetables and faecal-oral transmission through contaminated street/fast food. At discharge, most patients were in good health (79.7%), followed by moderate health (17.6%) and poor health (2.3%), with a minimal percentage dying before discharge (0.4%). The most common complications reported at admission and during hospitalisation included electrolyte imbalance (28.2%), followed by severe dehydration (16.3%). In the follow-up period, the majority of patients exhibited good health (81.0%). Older patients (>60 years) had poorer outcomes, with 8.4% having poor health and 4.2% death rate.
CONCLUSIONS: The study found results consistent with previous AWD outbreaks in developing countries like Yemen, Nigeria and Lebanon. Preventative measures like improving water sanitation and hygiene practices are essential to prevent future outbreaks and ease the strain on healthcare systems. Therefore, future studies must investigate the risk factors that increase the spread and the severity of the disease and investigate the best management method.
摘要：
目的：本研究的目的是描述在叙利亚最近爆发霍乱期间向阿勒颇大学医院（AUH）提供的急性水样腹泻（AWD）病例。
方法：前瞻性，观察,队列研究。
方法：在2022年9月20日至2022年10月20日期间，共有1061例AWD患者入院接受AUH治疗。数据收集是通过结构化问卷完成的。这包括全面的临床观察，实验室分析,治疗干预和整体病例评估。
结果：分析揭示了显著的见解：大部分患者（58.6%）是来自城市地区的居民，40.3%是来自农村地区的居民。有趣的是，从我们医院的患者数据中出现了各种各样的潜在感染源，包括不受控制的井水，蔬菜和粪便通过受污染的街头/快餐传播。出院时,大多数患者健康状况良好(79.7%)，其次是中度健康(17.6%)和不良健康(2.3%)，出院前死亡的百分比最小(0.4%)。入院时和住院期间报告的最常见并发症包括电解质失衡（28.2%），其次是严重脱水(16.3%)。在后续阶段,大多数患者表现出良好的健康状况(81.0%)。老年患者（>60岁）的预后较差，8.4%的人健康状况不佳，4.2%的死亡率。
结论：研究发现，结果与也门等发展中国家以前的AWD疫情一致，尼日利亚和黎巴嫩。改善水环境卫生和卫生习惯等预防措施对于防止未来疫情爆发和缓解医疗系统的压力至关重要。因此,未来的研究必须调查增加疾病传播和严重程度的危险因素，并研究最佳的管理方法。
方法：前瞻性，观察,队列研究。
方法：在2022年9月20日至2022年10月20日期间，共有1061例AWD患者入院接受AUH治疗。数据收集是通过结构化问卷完成的。这包括全面的临床观察，实验室分析,治疗干预和整体病例评估。
结果：分析揭示了显著的见解：大部分患者（58.6%）是来自城市地区的居民，40.3%是来自农村地区的居民。有趣的是，从我们医院的患者数据中出现了各种各样的潜在感染源，包括不受控制的井水，蔬菜和粪便通过受污染的街头/快餐传播。出院时,大多数患者健康状况良好(79.7%)，其次是中度健康(17.6%)和不良健康(2.3%)，出院前死亡的百分比最小(0.4%)。入院时和住院期间报告的最常见并发症包括电解质失衡（28.2%），其次是严重脱水(16.3%)。在后续阶段,大多数患者表现出良好的健康状况(81.0%)。老年患者（>60岁）的预后较差，8.4%的人健康状况不佳，4.2%的死亡率。
结论：研究发现，结果与也门等发展中国家以前的AWD疫情一致，尼日利亚和黎巴嫩。改善水环境卫生和卫生习惯等预防措施对于防止未来疫情爆发和缓解医疗系统的压力至关重要。因此,未来的研究必须调查增加疾病传播和严重程度的危险因素，并研究最佳的管理方法。
