Abstract：
We consider a model of basic inner retinal connectivity where bipolar and amacrine cells interconnect and both cell types project onto ganglion cells, modulating their response output to the brain visual areas. We derive an analytical formula for the spatiotemporal response of retinal ganglion cells to stimuli, taking into account the effects of amacrine cells inhibition. This analysis reveals two important functional parameters of the network: (1) the intensity of the interactions between bipolar and amacrine cells and (2) the characteristic timescale of these responses. Both parameters have a profound combined impact on the spatiotemporal features of retinal ganglion cells\' responses to light. The validity of the model is confirmed by faithfully reproducing pharmacogenetic experimental results obtained by stimulating excitatory DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) expressed on ganglion cells and amacrine cells\' subclasses, thereby modifying the inner retinal network activity to visual stimuli in a complex, entangled manner. Our mathematical model allows us to explore and decipher these complex effects in a manner that would not be feasible experimentally and provides novel insights in retinal dynamics.
摘要：
我们考虑了一个基本的内部视网膜连通性模型，其中双极和无长突细胞相互连接，并且两种细胞类型都投射到神经节细胞上，调节他们对大脑视觉区域的反应输出。我们推导了视网膜神经节细胞对刺激的时空反应的解析公式，考虑到无长突细胞的抑制作用。该分析揭示了网络的两个重要功能参数：（1）双极和无长突细胞之间相互作用的强度，以及（2）这些反应的特征时间尺度。这两个参数对视网膜神经节细胞对光的反应的时空特征具有深远的综合影响。该模型的有效性通过忠实再现通过刺激在神经节细胞和无长突细胞亚类上表达的兴奋性DREADDs（设计药物专门激活的设计受体）获得的药物遗传学实验结果来证实，从而将内部视网膜网络活动修改为复杂的视觉刺激，纠缠的方式。我们的数学模型使我们能够以实验上不可行的方式探索和破译这些复杂的效应，并提供视网膜动力学的新见解。
