Abstract：
Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification and degradation of all glycans in Nature. Advances in genomic and metagenomic methodologies, in conjunction with lower cost gene synthesis, have provided access to a steady stream of new CAZymes with both well-established and novel mechanisms. At the same time, increasing access to cryo-EM has resulted in exciting new structures, particularly of transmembrane glycosyltransferases of various sorts. This improved understanding has resulted in widespread progress in applications of CAZymes across diverse fields, including therapeutics, organ transplantation, foods, and biofuels. Herein, we highlight a few of the many important advances that have recently been made in the understanding and applications of CAZymes.
摘要：
碳水化合物活性酶（CAZymes）负责生物合成，自然界中所有聚糖的修饰和降解。基因组和宏基因组方法学的进展，结合低成本的基因合成，提供了源源不断的新的CAZymes，既有完善的机制，也有新颖的机制。同时,越来越多的人使用低温电磁技术产生了令人兴奋的新结构，特别是各种跨膜糖基转移酶。这种改进的理解导致了CAZymes在不同领域的应用的广泛进展，包括治疗，器官移植,食物,和生物燃料。在这里，我们强调了最近在理解和应用CAZymes方面取得的许多重要进展中的一些。
