Rapid Sequence Induction and Intubation

快速顺序诱导和插管
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  • 文章类型: Journal Article
    背景:当无法插管时,需要紧急的颈部气道前部(FONA),不能充氧危机发生。在特定情况下,FONA也可能是气道管理的主要选择。FONA有两种技术,有文献支持手术技术而不是经皮手术。幸运的是,由于死亡率很高,因此报告的院前FONA需求很少见。由于发病率低,关于FONA的文献在不同的设置方面是有限的,技术和运营商。作为未来研究和改善患者护理的基础,我们的目标是描述频率,适应症,技术,成功,以及芬兰直升机紧急医疗服务(HEMS)中FONA的结果。
    方法:这项回顾性描述性研究回顾了2012年1月至8.9月2019年在芬兰HEMS进行的FONA。芬兰HEMS由六个单元组成,主要由麻醉师组成。临床数据收集自国家HEMS数据库和波谷图综述。死亡率数据来自人口登记。仅进行描述性统计。
    结果:在研究期间共进行了22次FONA,7例患者为主要患者,14例在插管失败后进行(缺少有关一次尝试指示的数据)。这相当于0.13%(14/10,813)的抢救需要FONA和0.20%(22/10,813)的FONA率。除一个FONA外,所有FONA均采用手术方法(20/21,95%,缺失数据=1),全部成功(22/22,100%)。适应症主要为心脏骤停(10/22,45%)和外伤(6/22,27%),需要二次FONA的最常见原因是食物或液体阻塞气道(7/14,50%).现场死亡率为36%(8/22),30天死亡率为90%(19/21,缺失数据=1)。
    结论:在具有经验丰富的气道提供者的HEMS系统中,对FONA的需求很少。即使该过程已成功执行,死亡率明显较高。
    BACKGROUND: An emergent front of neck airway (FONA) is needed when a \'can\'t intubate, can\'t oxygenate\' crisis occurs. A FONA may also in specific cases be the primary choice of airway management. Two techniques exist for FONA, with literature favouring the surgical technique over the percutaneous. The reported need for a prehospital FONA is fortunately rare as the mortality has been shown to be high. Due to the low incidence, literature on FONA is limited with regards to different settings, techniques and operators. As a foundation for future research and improvement of patient care, we aim to describe the frequency, indications, technique, success, and outcomes of FONA in the Finnish helicopter emergency medical services (HEMS).
    METHODS: This retrospective descriptive study reviews FONA performed at the Finnish HEMS during 1.1.2012 to 8.9.2019. The Finnish HEMS consists of six units, staffed mainly by anaesthesiologists. Clinical data was gathered from a national HEMS database and trough chart reviews. Data on mortality was obtained from a population registry. Only descriptive statistics were performed.
    RESULTS: A total of 22 FONA were performed during the study period, 7 were primary and 14 performed after failure to intubate (missing data regarding indication for one attempt). This equals a 0.13 % (14/10,813) need for a rescue FONA and a rate of 0.20 % (22/10,813) FONA out of all advanced airway management. All but one FONA was performed using a surgical approach (20/21, 95 %, missing data = 1) and all were successful (22/22, 100 %). Indications were mainly cardiac arrest (10/22, 45 %) and trauma (6/22, 27 %), and the most common reason for a need for a secondary FONA was obstruction of airway by food or fluids (7/14, 50 %). On-scene mortality was 36 % (8/22) and 30-day mortality 90 % (19/21, missing data = 1).
    CONCLUSIONS: The need for FONA is scarce in a HEMS system with experienced airway providers. Even though the procedure is successfully performed, the mortality is markedly high.
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  • 文章类型: Journal Article
    用瑞马唑仑和芬太尼系列阿片类药物诱导的麻醉可以用氟马西尼和纳洛酮逆转。罗库溴铵的伴随性麻痹可以促进气管插管,而sugammadex则是可逆的。一起,这种组合可能提供“常规”或“快速序列”诱导麻醉的完全可逆性。这是否有用,甚至是安全的,需要仔细评估。
    Anaesthesia induced with remimazolam and a fentanyl-series opioid can be reversed with flumazenil and naloxone. Concomitant paralysis with rocuronium can facilitate tracheal intubation whilst being reversible with sugammadex. Together, this combination might offer full reversibility of a \'routine\' or a \'rapid-sequence\' induction anaesthesia. Whether this is useful, or even safe, requires careful evaluation.
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  • 文章类型: Journal Article
    目的:快速序列插管(RSI)是美国航空医疗团队通常执行的一项关键技能。为了提高安全性并减少潜在的患者伤害,重症监护室的各个机构已实施了清单,急诊科,甚至院前空气医疗计划。然而,文献提示,RSI前使用检查表并未显示医院临床重要结局的改善.目前尚不清楚院前环境中航空医务人员使用RSI检查表是否会带来任何临床上重要的益处。
    方法:该机构审查委员会批准的项目是在大型直升机救护公司内进行的前后观察性研究。飞行机组人员(飞行护理人员/护士)使用RSI清单超过3年。检查表实施前8个季度和实施后8个季度的数据进行了评估,从2014年12月到2019年3月。收集数据,包括在插管尝试期间自我报告使用检查表,插管的原因,与困难的气道预测因子(HEAVEN[低氧血症,极端的大小,解剖中断,呕吐,失血,颈部活动/神经系统损伤]标准),并与实施前气道管理检查表进行比较。与在清单之前接受RSI的人相比,主要结果是改善了首过成功(FPS)。次要结果是在实施RSI检查表之前和之后,在成年患者中第一次通过时发现明确的气道无缺氧改善。记录RSI后结果情景,以分析和验证检查表的有效性。
    结果:在研究期间尝试了一万四百五个插管。在RSI检查表实施之前,90.9%的患者获得了FPS,93.3%的人在RSI检查表中实现了FPS后(P≤.001)。在预实现时期,36.2%的患者没有HEAVEN预测因子,而RSI检查表实施后为31.5%。这些数据表明,在RSI检查表实施之前,气道被定义为比实施后难度小。
    结论:实施标准化的RSI清单可以更好地识别威慑因素,提供有效和准确的行动促进FPS。我们的数据表明,当发现困难的气道时,使用RSI检查表提高了FPS,从而减少不良事件。
    OBJECTIVE: Rapid sequence intubation (RSI) is a critical skill commonly performed by air medical teams in the United States. To improve safety and reduce potential patient harm, checklists have been implemented by various institutions in intensive care units, emergency departments, and even prehospital air medical programs. However, the literature suggests that checklist use before RSI has not shown improvement in clinically important outcomes in the hospital. It is unclear if RSI checklist use by air medical crews in prehospital environments confers any clinically important benefit.
    METHODS: This institutional review board-approved project is a before-and-after observational study conducted within a large helicopter ambulance company. The RSI checklist was used by flight crewmembers (flight paramedic/nurse) for over 3 years. Data were evaluated for 8 quarters before and 8 quarters after checklist implementation, spanning December 2014 to March 2019. Data were collected, including the self-reported use of the checklist during intubation attempts, the reason for intubation, and correlation with difficult airway predictors (HEAVEN [Hypoxemia, Extremes of size, Anatomic disruption, Vomit, Exsanguination, Neck mobility/Neurologic injury] criteria), and compared with airway management before the implementation of the checklist. The primary outcome was improved first-pass success (FPS) when compared among those who received RSI before the checklist versus those who received RSI with the checklist. The secondary outcome was a definitive airway sans hypoxia improvement noted on the first pass among adult patients as measured before and after RSI checklist implementation. Post-RSI outcome scenarios were recorded to analyze and validate the effectiveness of the checklist.
    RESULTS: Ten thousand four hundred five intubations were attempted during the study. FPS was achieved in 90.9% of patients before RSI checklist implementation, and 93.3% achieved FPS postimplementation of the RSI checklist (P ≤ .001). In the preimplementation epoch, 36.2% of patients had no HEAVEN predictors versus 31.5% after RSI checklist implementation. These data showed that before RSI checklist implementation, airways were defined as less difficult than after implementation.
    CONCLUSIONS: The implementation of a standardized RSI checklist provided a better identification of deterring factors, affording efficient and accurate actions promoting FPS. Our data suggest that when a difficult airway is identified, using the RSI checklist improves FPS, thereby reducing adverse events.
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  • 文章类型: Journal Article
    目标:高级气道管理,包括使用快速序列插管(RSI),是复苏的基础。然而,报道的儿科气道管理经验有限,因为儿童急诊RSI手术数量相对较少.这项研究的目的是在大型航空医疗数据库中记录儿科RSI的经验,并探索改进的机会。
    方法:将2015年至2019年期间由航空医务人员接受RSI的所有儿科患者(年龄<18岁)纳入本分析。将受试者先验分为3个年龄亚组(0-2岁,3-8年,和9-17岁)。感兴趣的主要变量包括总体插管成功,首次尝试插管成功,首次尝试插管成功而没有去饱和。还探讨了正压通气(PPV)用于预氧合和氧去饱和的速率。
    结果:共纳入1,091例小儿RSI患者。总体插管成功率为98%(0-2年=96%,3-8年=97%,9-17岁=98%),91%的人在第一次尝试时插管(0-2年=86%,3-8年=90%,和9-17年=92%)和87%在没有氧气去饱和的第一次尝试插管(0-2年=80%,3-8年=88%,9-17岁=90%)。观察到插管成功率急剧下降,所有患者的预氧合SpO2值<97%。年轻患者(0-2岁)的初始SpO2值较低,并且有或没有去饱和的首次尝试成功率降低。这些患者在预充氧尝试期间接受PPV的可能性较小,并且在初次插管尝试时使用视频喉镜或探条较少。
    结论:在这项研究中,我们记录了空气医学儿科RSI的高成功率。在预氧合过程中,较高的目标SpO2值可能是合理的。插管成功,PPV用于预充氧,视频喉镜,年轻患者使用探床的比例较低。
    OBJECTIVE: Advanced airway management, including the use of rapid sequence intubation (RSI), is fundamental in resuscitation. However, the reported experience with pediatric airway management is limited because of the relatively low number of emergency RSI procedures in children. The aim of this study was to document the experience with pediatric RSI in a large air medical database and explore opportunities for improvement.
    METHODS: All pediatric patients (age < 18 years) undergoing RSI by air medical crews between 2015 and 2019 were included in this analysis. Subjects were divided a priori into 3 age subgroups (0-2 years, 3-8 years, and 9-17 years). The primary variables of interest included overall intubation success, first-attempt intubation success, and first-attempt intubation success without desaturation. The rates of positive-pressure ventilation (PPV) use for preoxygenation and oxygen desaturation were also explored.
    RESULTS: A total of 1,091 pediatric RSI patients were included. The overall intubation success rate was 98% (0-2 years = 96%, 3-8 years = 97%, and 9-17 years = 98%), with 91% intubated on the first attempt (0-2 years = 86%, 3-8 years = 90%, and 9-17 years = 92%) and 87% intubated on the first attempt without oxygen desaturation (0-2 years = 80%, 3-8 years = 88%, and 9-17 years = 90%). A sharp decline in intubation success was observed with preoxygenation SpO2 values < 97% across all patients. Younger patients (0-2 years) had lower initial SpO2 values and decreased first-attempt success rates with and without desaturation. These patients were less likely to receive PPV during preoxygenation attempts and had lower use of video laryngoscopy or a bougie on the initial intubation attempt.
    CONCLUSIONS: In this study, we documented high success rates for air medical pediatric RSI. Higher target SpO2 values may be justified during preoxygenation. Intubation success, PPV use for preoxygenation, video laryngoscopy, and the use of a bougie were lower for younger patients.
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  • 文章类型: Journal Article
    背景:院前麻醉是对危重患者实施的复杂干预措施。为了尽量减少并发症,概述该过程的标准操作程序(SOP)被认为是有价值的。我们调查了直升机紧急医疗服务(HEMS)中院前麻醉SOP的实施情况。
    方法:我们于2012年1月至2019年8月对接受芬兰HEMS院前麻醉的患者进行了一项回顾性观察性研究。研究的干预措施是在2015-2016年期间在五个基地中的两个基地实施SOP。根据患者之前是否麻醉进行分层,实施过程中或实施后,主要结局为1日和30日死亡率.次要结果包括麻醉质量指标。混杂因素通过logistic回归进行评估。
    结果:共进行了3902次气管插管,没有进行SOP,在实施期间为430,在实施之后为1525。SOP在实施过程中对1天死亡率有显著影响,比值比(OR)为0.56,95%置信区间(95%CI)为0.37-0.81,实施后有进一步的获益趋势(OR0.84,95%CI0.68-1.04),但30天死亡率无差异(实施后OR1.10,95%CI0.92-1.30)。SOP的实施将首过成功率从87.3%提高到96.5%,p<0.001。
    结论:实施院前麻醉SOP与降低1天死亡率和提高首过成功率的趋势相关,但不影响30天死亡率。尽管如此,我们提倡院前系统考虑实施院前麻醉SOP,因为即时性能指标显著改善.
    BACKGROUND: Prehospital anaesthesia is a complex intervention performed for critically ill patients. To minimise complications, a standard operating procedure (SOP) outlining the process is considered valuable. We investigated the implementation of an SOP for prehospital anaesthesia in helicopter emergency medical services (HEMS).
    METHODS: We performed a retrospective observational study of patients receiving prehospital anaesthesia by Finnish HEMS from January 2012 to August 2019. The intervention studied was the implementation of an SOP at two of the five bases during 2015-2016. Patients were stratified according to whether they were anaesthetised before, during or after implementation and the primary outcomes were 1- and 30-day mortality. Secondary outcomes included anaesthesia quality indicators. Confounding factors was assessed via logistic regression.
    RESULTS: A total of 3902 tracheal intubations were performed without an SOP, 430 during implementation and 1525 after implementation. The SOP had a significant effect on 1-day mortality during implementation with an odds ratio (OR) of 0.56, 95% confidence interval (95% CI) 0.37-0.81 and a further trend towards benefit after implementation (OR 0.84, 95% CI 0.68-1.04), but no difference in 30-day mortality (OR after implementation 1.10, 95% CI 0.92-1.30). Implementation of an SOP improved first-pass success rate from 87.3% to 96.5%, p < 0.001.
    CONCLUSIONS: Implementation of an SOP for prehospital anaesthesia was associated with a trend towards lower 1-day mortality and an improved first-pass success but did not affect 30-day mortality. Despite this, we advocate prehospital systems to consider implementation of a prehospital anaesthesia SOP as immediate performance markers improved significantly.
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  • 文章类型: Case Reports
    在这个案例报告中,我们描述了两种困难的插管,其中气管内导管穿过作为探条的纤维支气管镜。我们的病人最初表现为颈部伸展有限,狭窄的开口,和声门区域的限制视图。当患者通过喉罩充氧时,纤维支气管镜被引导通过。在示波器提供了无限制的声带视图之后,通过切割光纤线来移除数字模块,气管导管通过。正确确认气管导管位置后,插管被认为是成功的,因此,我们分享我们的新技术的经验。这种技术可以潜在地改善关键患者的预后,无论是在创伤还是意外困难的插管中。
    In this case report, we describe two difficult intubations in which an endotracheal tube was threaded over a fiberoptic bronchoscope that was acting as a bougie. Our patients initially presented with limited neck extension, narrow mouth opening, and restricted view of the glottic region. A fiberoptic bronchoscope was guided through while the patient was oxygenated through a laryngeal mask. After the scope provided an unrestricted view of the vocal cords, the digital module was removed by cutting the fiberoptic thread, and an endotracheal tube was passed through. After proper confirmation of the endotracheal tube position, the intubation was deemed successful and thereby, we share our experience with the novel technique. This technique may potentially improve critical patient outcomes whether in trauma or an unexpectedly difficult intubation.
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  • 文章类型: Journal Article
    目的:在我们的研究中,我们的目的是比较标准的快速顺序插管方案和应用罗库溴铵引发技术对手术时间和血流动力学的影响。
    方法:应用于急诊科并需要快速顺序插管的患者被纳入我们的研究,我们进行了随机对照设计。研究中的随机化是根据病例的到达顺序进行的。标准组进行快速顺序插管。在启动组中,在诱导剂之前约3分钟施用10%的罗库溴铵剂量。插管时间,使用的药物数量,生命体征,记录用于确认插管的插管前后的呼气末CO2水平。
    结果:本研究共纳入52例患者,其中26例患者被纳入标准组,26例患者被纳入启动组。标准组插管时间为121.2±21.9s,启动组计算为68.4±11.6s(p<0.001)。标准组插管后平均动脉压为58.3±26.6mmHg,启动组为80.6±21.1mmHg(p=0.002)。
    结论:观察到罗库溴铵的灌注缩短了插管时间,并更好地保持了血流动力学曲线。
    背景:NCT05343702。
    OBJECTIVE: In our study, we aimed to compare the effect of standard rapid sequence intubation protocol and the application of rocuronium priming technique on the procedure time and hemodynamic profile.
    METHODS: Patients who applied to the emergency department and needed rapid sequence intubation were included in our study, which we conducted with a randomized controlled design. Randomization in the study was made according to the order of arrival of the cases. Rapid sequence intubation was performed in the standard group. In the priming group, 10% of the rocuronium dose was administered approximately 3 min before the induction agent. Intubation time, amount of drug used, vital signs, and end-tidal CO2 level before and after intubation used to confirm intubation were recorded.
    RESULTS: A total of 52 patients were included in the study, of which 26 patients were included in the standard group and 26 patients in the priming group. While intubation time was 121.2±21.9 s in the standard group, it was calculated as 68.4±11.6 s in the priming group (p<0.001). While the mean arterial pressure was 58.3±26.6 mmHg in the standard group after intubation, it was 80.6±21.1 mmHg in the priming group (p=0.002).
    CONCLUSIONS: It was observed that priming with rocuronium shortened the intubation time and preserved the hemodynamic profile better.
    BACKGROUND: NCT05343702.
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