PDF(Pubmed)
Abstract：
BACKGROUND: Although there are some data regarding the COVID-19 vaccine and in in vitro fertilization (IVF) treatments, its potential impact in terms of serum immunoglobulin G (IgG) levels has not been evaluated prospectively. This study aimed to assess the effect of COVID-19 vaccine and IgG levels on IVF outcomes.
METHODS: This observational, cohort study was conducted at a referral IVF unit. Couples undergoing IVF treatment during the COVID-19 vaccination period were recruited from March-April 2021. The study compared 38 women who had received the Pfizer mRNA COVID-19 vaccination to 10 women who had not and were not infected by the virus. We also compared pre- and post-vaccination IVF treatments for 24 women. The relation between serologic titers and IVF treatment outcomes was also assessed.
RESULTS: No significant difference was found between the vaccinated and unvaccinated/uninfected groups regarding the main outcome measures. However, there was a trend toward a higher pregnancy rate for the unvaccinated group (57% vs. 23%, p = 0.078) but no difference in delivery rate (p = 0.236), gestational week (p = 0.537) or birth rate (p = 0.671).
CONCLUSIONS: We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.
METHODS: This observational, cohort study was conducted at a referral IVF unit. Couples undergoing IVF treatment during the COVID-19 vaccination period were recruited from March-April 2021. The study compared 38 women who had received the Pfizer mRNA COVID-19 vaccination to 10 women who had not and were not infected by the virus. We also compared pre- and post-vaccination IVF treatments for 24 women. The relation between serologic titers and IVF treatment outcomes was also assessed.
RESULTS: No significant difference was found between the vaccinated and unvaccinated/uninfected groups regarding the main outcome measures. However, there was a trend toward a higher pregnancy rate for the unvaccinated group (57% vs. 23%, p = 0.078) but no difference in delivery rate (p = 0.236), gestational week (p = 0.537) or birth rate (p = 0.671).
CONCLUSIONS: We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.
摘要：
背景：尽管有一些关于COVID-19疫苗和体外受精（IVF）治疗的数据，其对血清免疫球蛋白G(IgG)水平的潜在影响尚未进行前瞻性评估.这项研究旨在评估COVID-19疫苗和IgG水平对IVF结局的影响。
方法：这种观察，队列研究在转诊IVF病房进行.从2021年3月至4月招募了在COVID-19疫苗接种期间接受IVF治疗的夫妇。该研究比较了38名接受过辉瑞mRNACOVID-19疫苗接种的女性和10名没有感染过这种病毒的女性。我们还比较了24名女性接种前和接种后的IVF治疗方法。还评估了血清学滴度与IVF治疗结果之间的关系。
结果：在主要结果测量方面，在接种和未接种/未感染组之间没有发现显着差异。然而,未接种疫苗组有更高的妊娠率趋势(57%vs.23%,p=0.078)，但交货率没有差异(p=0.236)，孕周（p=0.537）或出生率（p=0.671）。
结论：我们谨慎声明，COVID-19mRNA疫苗不会影响生育结局，包括受精,妊娠率和分娩率，产科结果，和精液参数，无论测量的IgG水平。
方法：这种观察，队列研究在转诊IVF病房进行.从2021年3月至4月招募了在COVID-19疫苗接种期间接受IVF治疗的夫妇。该研究比较了38名接受过辉瑞mRNACOVID-19疫苗接种的女性和10名没有感染过这种病毒的女性。我们还比较了24名女性接种前和接种后的IVF治疗方法。还评估了血清学滴度与IVF治疗结果之间的关系。
结果：在主要结果测量方面，在接种和未接种/未感染组之间没有发现显着差异。然而,未接种疫苗组有更高的妊娠率趋势(57%vs.23%,p=0.078)，但交货率没有差异(p=0.236)，孕周（p=0.537）或出生率（p=0.671）。
结论：我们谨慎声明，COVID-19mRNA疫苗不会影响生育结局，包括受精,妊娠率和分娩率，产科结果，和精液参数，无论测量的IgG水平。
