%0 Journal Article
%T Does the SARS-CoV-2 mRNA vaccine and its serum IgG levels affect fertility treatments and obstetric outcomes? An observational cohort study.
%A Miller ND
%A Goren Gepstein N
%A Cohen D
%A Haikin Herzberger E
%A Shalev Ram H
%A Mashiach Friedler J
%A Sharon Weiner M
%A Rahav R
%A Indenbaum V
%A Lustig Y
%A Wiser A
%J Clin Exp Med
%V 24
%N 1
%D 2024 Apr 23
%M 38653875
%F 5.057
%R 10.1007/s10238-024-01345-9
%X <B>BACKGROUND: </B>Although there are some data regarding the COVID-19 vaccine and in in vitro fertilization (IVF) treatments, its potential impact in terms of serum immunoglobulin G (IgG) levels has not been evaluated prospectively. This study aimed to assess the effect of COVID-19 vaccine and IgG levels on IVF outcomes.<BR><B>METHODS: </B>This observational, cohort study was conducted at a referral IVF unit. Couples undergoing IVF treatment during the COVID-19 vaccination period were recruited from March-April 2021. The study compared 38 women who had received the Pfizer mRNA COVID-19 vaccination to 10 women who had not and were not infected by the virus. We also compared pre- and post-vaccination IVF treatments for 24 women. The relation between serologic titers and IVF treatment outcomes was also assessed.<BR><B>RESULTS: </B>No significant difference was found between the vaccinated and unvaccinated/uninfected groups regarding the main outcome measures. However, there was a trend toward a higher pregnancy rate for the unvaccinated group (57% vs. 23%, p = 0.078) but no difference in delivery rate (p = 0.236), gestational week (p = 0.537) or birth rate (p = 0.671).<BR><B>CONCLUSIONS: </B>We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.