{Reference Type}: Journal Article
{Title}: Does the SARS-CoV-2 mRNA vaccine and its serum IgG levels affect fertility treatments and obstetric outcomes? An observational cohort study.
{Author}: Miller ND;Goren Gepstein N;Cohen D;Haikin Herzberger E;Shalev Ram H;Mashiach Friedler J;Sharon Weiner M;Rahav R;Indenbaum V;Lustig Y;Wiser A;
{Journal}: Clin Exp Med
{Volume}: 24
{Issue}: 1
{Year}: 2024 Apr 23
{Factor}: 5.057
{DOI}: 10.1007/s10238-024-01345-9
{Abstract}: <B>BACKGROUND: </B>Although there are some data regarding the COVID-19 vaccine and in in vitro fertilization (IVF) treatments, its potential impact in terms of serum immunoglobulin G (IgG) levels has not been evaluated prospectively. This study aimed to assess the effect of COVID-19 vaccine and IgG levels on IVF outcomes.<BR><B>METHODS: </B>This observational, cohort study was conducted at a referral IVF unit. Couples undergoing IVF treatment during the COVID-19 vaccination period were recruited from March-April 2021. The study compared 38 women who had received the Pfizer mRNA COVID-19 vaccination to 10 women who had not and were not infected by the virus. We also compared pre- and post-vaccination IVF treatments for 24 women. The relation between serologic titers and IVF treatment outcomes was also assessed.<BR><B>RESULTS: </B>No significant difference was found between the vaccinated and unvaccinated/uninfected groups regarding the main outcome measures. However, there was a trend toward a higher pregnancy rate for the unvaccinated group (57% vs. 23%, p = 0.078) but no difference in delivery rate (p = 0.236), gestational week (p = 0.537) or birth rate (p = 0.671).<BR><B>CONCLUSIONS: </B>We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.