Abstract：
BACKGROUND: Chronic recurrent cystitis (CRC) is a complex multifaceted problem of modern uroinfectology.
OBJECTIVE: To study the immunological parameters of urine in patients with chronic recurrent cystitis depending on the etiological factor.
METHODS: The prospective study included 71 patients aged 20-45 years who had previously been diagnosed with recurrent lower urinary tract infection: chronic recurrent cystitis (CRC) during an exacerbation period. Based on the results of bacteriological and PCR studies of urine, scraping of the urethra and vagina, depending on the dominant etiological factor, the patients were divided into three groups: group 1 (n=30) - with papillomavirus CRC (PVI-CRC), group 2 (n=30) - with bacterial CRC (B - CRC), group 3 (n=11) - with candida CRC (C - CRC). Analysis of the assessment of immunological parameters of urine was carried out using an enzyme-linked immunosorbent assay (ELISA-BEST).
RESULTS: Based on the results of an immunological study of urine in the study groups, characteristic specific changes in the level of interleukins and interferons were identified, which made it possible to determine a protocol for the differential diagnosis of CRC.
CONCLUSIONS: Our study shows the advisability of testing interleukins in urine (IL-1 beta, IL-6, IL-8); these indicators can serve as scoring criteria in the differential diagnosis of CRC of various origins.
CONCLUSIONS: , it is reasonable to study the level of IFN-2b and IFN; when identifying the functional inferiority of the IFN system in women with CRC, correction of the IFN system is necessary.
OBJECTIVE: To study the immunological parameters of urine in patients with chronic recurrent cystitis depending on the etiological factor.
METHODS: The prospective study included 71 patients aged 20-45 years who had previously been diagnosed with recurrent lower urinary tract infection: chronic recurrent cystitis (CRC) during an exacerbation period. Based on the results of bacteriological and PCR studies of urine, scraping of the urethra and vagina, depending on the dominant etiological factor, the patients were divided into three groups: group 1 (n=30) - with papillomavirus CRC (PVI-CRC), group 2 (n=30) - with bacterial CRC (B - CRC), group 3 (n=11) - with candida CRC (C - CRC). Analysis of the assessment of immunological parameters of urine was carried out using an enzyme-linked immunosorbent assay (ELISA-BEST).
RESULTS: Based on the results of an immunological study of urine in the study groups, characteristic specific changes in the level of interleukins and interferons were identified, which made it possible to determine a protocol for the differential diagnosis of CRC.
CONCLUSIONS: Our study shows the advisability of testing interleukins in urine (IL-1 beta, IL-6, IL-8); these indicators can serve as scoring criteria in the differential diagnosis of CRC of various origins.
CONCLUSIONS: , it is reasonable to study the level of IFN-2b and IFN; when identifying the functional inferiority of the IFN system in women with CRC, correction of the IFN system is necessary.
摘要：
背景：慢性复发性膀胱炎（CRC）是现代泌尿系统感染的一个复杂的多方面问题。
目的：研究慢性复发性膀胱炎患者的尿液免疫学指标及其病因。
方法：前瞻性研究包括71名年龄在20-45岁之间的患者，这些患者先前被诊断为急性加重期的复发性下尿路感染：慢性复发性膀胱炎（CRC）。根据尿液细菌学和PCR研究的结果，刮除尿道和阴道，根据主要病因，患者分为三组：第1组（n=30）-乳头状瘤病毒CRC（PVI-CRC），第2组（n=30）-细菌性CRC（B-CRC），第3组（n=11）-念珠菌CRC（C-CRC）。使用酶联免疫吸附测定（ELISA-BEST）进行尿液免疫学参数评估的分析。
结果：根据对研究组尿液的免疫学研究结果，鉴定了白细胞介素和干扰素水平的特征性特异性变化，这使得确定鉴别诊断CRC的方案成为可能。
结论：我们的研究表明检测尿液中白细胞介素（IL-1β，IL-6，IL-8）；这些指标可以作为各种来源的CRC的鉴别诊断的评分标准。
结论：，研究IFN-2b和IFN的水平是合理的；在确定患有CRC的女性的IFN系统的功能劣势时，校正IFN系统是必要的。
目的：研究慢性复发性膀胱炎患者的尿液免疫学指标及其病因。
方法：前瞻性研究包括71名年龄在20-45岁之间的患者，这些患者先前被诊断为急性加重期的复发性下尿路感染：慢性复发性膀胱炎（CRC）。根据尿液细菌学和PCR研究的结果，刮除尿道和阴道，根据主要病因，患者分为三组：第1组（n=30）-乳头状瘤病毒CRC（PVI-CRC），第2组（n=30）-细菌性CRC（B-CRC），第3组（n=11）-念珠菌CRC（C-CRC）。使用酶联免疫吸附测定（ELISA-BEST）进行尿液免疫学参数评估的分析。
结果：根据对研究组尿液的免疫学研究结果，鉴定了白细胞介素和干扰素水平的特征性特异性变化，这使得确定鉴别诊断CRC的方案成为可能。
结论：我们的研究表明检测尿液中白细胞介素（IL-1β，IL-6，IL-8）；这些指标可以作为各种来源的CRC的鉴别诊断的评分标准。
结论：，研究IFN-2b和IFN的水平是合理的；在确定患有CRC的女性的IFN系统的功能劣势时，校正IFN系统是必要的。
