PDF(Pubmed)
Abstract：
The American lobster, Homarus americanus, is not only of considerable economic importance but has also emerged as a premier model organism in neuroscience research. Neuropeptides, an important class of cell-to-cell signaling molecules, play crucial roles in a wide array of physiological and psychological processes. Leveraging the recently sequenced high-quality draft genome of the American lobster, our study sought to profile the neuropeptidome of this model organism. Employing advanced mass spectrometry techniques, we identified 24 neuropeptide precursors and 101 unique mature neuropeptides in Homarus americanus. Intriguingly, 67 of these neuropeptides were discovered for the first time. Our findings provide a comprehensive overview of the peptidomic attributes of the lobster\'s nervous system and highlight the tissue-specific distribution of these neuropeptides. Collectively, this research not only enriches our understanding of the neuronal complexities of the American lobster but also lays a foundation for future investigations into the functional roles that these peptides play in crustacean species. The mass spectrometry data have been deposited in the PRIDE repository with the identifier PXD047230.
摘要：
美国龙虾,美洲人马罗斯，不仅具有相当大的经济重要性，而且已经成为神经科学研究中的首要模型生物。神经肽,一类重要的细胞间信号分子，在广泛的生理和心理过程中起着至关重要的作用。利用最近测序的美国龙虾的高质量基因组草案，我们的研究试图描述这种模式生物的神经肽组.采用先进的质谱技术，我们在美洲人鱼中鉴定出24种神经肽前体和101种独特的成熟神经肽。有趣的是，其中67种神经肽首次被发现。我们的发现提供了龙虾神经系统的肽属性的全面概述，并强调了这些神经肽的组织特异性分布。总的来说，这项研究不仅丰富了我们对美国龙虾神经元复杂性的理解，而且为未来研究这些肽在甲壳类物种中的功能作用奠定了基础。质谱数据已与标识符PXD047230一起存放在PRIDE存储库中。
