Abstract：
Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.
摘要：
Tenascin-C（TNC）是一种在病理条件下高度表达的基质细胞和多模块糖蛋白，尤其是癌症和慢性炎症性疾病。长期以来，TNC被认为是抗癌治疗中诊断和治疗方法的有希望的靶标，并且已经在癌症患者的临床试验中广泛靶向。这篇综述概述了目前用于TNC检测和抗TNC治疗方法的最先进策略，包括一些先进的临床策略。我们还讨论了新的治疗方案，靶向TNC的免疫调节功能可能是中心阶段。
