{Reference Type}: Journal Article
{Title}: Tenascin-C targeting strategies in cancer.
{Author}: Dhaouadi S;Bouhaouala-Zahar B;Orend G;
{Journal}: Matrix Biol
{Volume}: 130
{Issue}: 0
{Year}: 2024 Jun 18
{Factor}: 10.447
{DOI}: 10.1016/j.matbio.2024.04.002
{Abstract}: Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.