%0 Journal Article
%T Tenascin-C targeting strategies in cancer.
%A Dhaouadi S
%A Bouhaouala-Zahar B
%A Orend G
%J Matrix Biol
%V 130
%N 0
%D 2024 Jun 18
%M 38642843
%F 10.447
%R 10.1016/j.matbio.2024.04.002
%X Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.