PDF(Pubmed)
Abstract：
Humans have the remarkable ability to vividly retrieve sensory details of past events. According to the theory of sensory reinstatement, during remembering, brain regions specialized for processing specific sensory stimuli are reactivated to support content-specific retrieval. Recently, several studies have emphasized transformations in the spatial organization of these reinstated activity patterns. Specifically, studies of scene stimuli suggest a clear anterior shift in the location of retrieval activations compared with the activity observed during perception. However, it is not clear that such transformations occur universally, with inconsistent evidence for other important stimulus categories, particularly faces. One challenge in addressing this question is the careful delineation of face-selective cortices, which are interdigitated with other selective regions, in configurations that spatially differ across individuals. Therefore, we conducted a multisession neuroimaging study to first carefully map individual participants\' (nine males and seven females) face-selective regions within ventral temporal cortex (VTC), followed by a second session to examine the activity patterns within these regions during face memory encoding and retrieval. While face-selective regions were expectedly engaged during face perception at encoding, memory retrieval engagement exhibited a more selective and constricted reinstatement pattern within these regions, but did not show any consistent direction of spatial transformation (e.g., anteriorization). We also report on unique human intracranial recordings from VTC under the same experimental conditions. These findings highlight the importance of considering the complex configuration of category-selective cortex in elucidating principles shaping the neural transformations that occur from perception to memory.
摘要：
人类具有生动地检索过去事件的感官细节的非凡能力。根据感官恢复理论，在记忆过程中,专门用于处理特定感官刺激的大脑区域被重新激活以支持特定内容的检索。最近,一些研究强调了这些恢复的活动模式的空间组织的转变。具体来说,对场景刺激的研究表明，与感知过程中观察到的活动相比，检索激活的位置有明显的前移。然而,尚不清楚这种转变是否普遍发生，其他重要刺激类别的证据不一致，尤其是面孔。解决这个问题的一个挑战是仔细划定面部选择性皮质，它们与其他选择区域相互交叉，在空间上不同个体的配置中。因此,我们进行了多节神经影像学研究，首先仔细绘制个体参与者（9名男性和7名女性）在腹颞叶皮层（VTC）内的面部选择区域，然后是第二个会话，以检查在面部记忆编码和检索期间这些区域内的活动模式。虽然面部选择区域预计在编码时参与面部感知，记忆恢复参与在这些区域内表现出更具选择性和收缩性的恢复模式，但没有显示任何一致的空间变换方向(例如，先行)。我们还报告了在相同实验条件下来自VTC的独特人类颅内记录。这些发现强调了在阐明从感知到记忆发生的神经转换的原理时，考虑类别选择皮层的复杂配置的重要性。意义陈述感官恢复表明，参与刺激的初始感官处理的大脑区域被重新激活以支持成功的记忆检索。然而,最近的研究结果表明，恢复的皮层激活发生在感知驱动的活动之前，特别是场景刺激。目前还不清楚这种超前是否发生在其他刺激中，比如面孔。为了解决这个问题，我们进行了多节功能磁共振成像研究，以识别腹颞叶皮层中的面部选择区域，并检查了恢复面部记忆期间这些区域内的活动。结果表明，检索活动与感知神经底物密切相关，确认个体特定的面部选择区域，而没有一致的空间偏移。这强调了在研究感知记忆转换的神经基础时考虑各个功能组织的重要性。
