PDF(Pubmed)
Abstract：
Vitamin D reduces prostaglandin levels and inflammation, making it a promising treatment option for dysmenorrhoea. However, its effects on pain intensity in different types of dysmenorrhoea remain unclear. We examined whether vitamin D supplementation decreases pain intensity in patients with dysmenorrhoea. The Cochrane Library, Embase, Google Scholar, Medline, and Scopus databases were searched from inception to 30 December 2023. Randomised controlled trials (RCTs) evaluating vitamin D supplementation effects on such patients were included. The primary and secondary outcomes were measured by the changes in pain intensity and rescue analgesic use, respectively. Pooled mean differences and rate ratios were calculated using a random-effect model; trial sequential analysis (TSA) was also performed. Overall, 11 studies involving 687 participants were included. Vitamin D supplementation significantly decreased pain intensity in patients with dysmenorrhoea compared with controls (pooled mean difference, -1.64; 95% confidence interval, -2.27 to -1.00; p < 0.001; CoE, moderate; I2 statistic, 79.43%) and indicated substantial heterogeneity among the included studies. TSA revealed that the current RCTs provide sufficient information. In subgroup analyses, vitamin D supplement reduced primary dysmenorrhoea pain but not secondary dysmenorrhoea pain. In conclusion, although substantial heterogeneity persists, vitamin D supplementation decreased pain intensity in patients with dysmenorrhea, especially in those with primary dysmenorrhoea.
摘要：
维生素D降低前列腺素水平和炎症，使其成为痛经的有希望的治疗选择。然而,其对不同类型痛经疼痛强度的影响尚不清楚。我们研究了补充维生素D是否能降低痛经患者的疼痛强度。科克伦图书馆,Embase,谷歌学者，Medline,和Scopus数据库从开始到2023年12月30日进行了搜索。包括评估维生素D补充对此类患者的影响的随机对照试验（RCT）。主要和次要结局是通过疼痛强度和抢救镇痛药使用的变化来衡量的。分别。使用随机效应模型计算集合均值差异和比率；还进行了试验序贯分析（TSA）。总的来说,11项研究涉及687名参与者。与对照组相比，补充维生素D显着降低了痛经患者的疼痛强度（汇总平均差异，-1.64；95%置信区间，-2.27至-1.00；p<0.001；CoE，中等；I2统计量，79.43%)，并表明纳入研究之间存在实质性异质性。TSA透露，目前的RCT提供了足够的信息。在亚组分析中，补充维生素D可减少原发性痛经疼痛，但不减少继发性痛经疼痛。总之,尽管巨大的异质性仍然存在，补充维生素D可降低痛经患者的疼痛强度，尤其是原发性痛经患者。
