METHODS: This study used enzyme-linked immunosorbent assays (ELISA) to examine smallpox and mpox antibodies in Koreans with three different age groups. We analyzed 56 sera obtained from a tertiary care hospital in South Korea between September 2022 and April 2023. Plasma levels of antibodies against the viral proteins of smallpox (variola cytokine response-modifying protein B) and MPXV (A29) were measured using enzyme-linked immunosorbent assays.
RESULTS: Plasma samples from participants in their early 40 s and older exhibited higher reactivity to viral antigens than those from younger participants. Furthermore, there was a strong positive correlation in antibody positivity for the two different viruses across the sera.
CONCLUSIONS: The presence of low antibody levels in participants ˂40 years may hinder their ability to defend against OPXV. Therefore, it is imperative to implement effective public health measures to mitigate the transmission of OPXV within the community. These findings serve as fundamental information for devising strategies to combat mpox efficiently, particularly in regions where the virus is not prevalent.
方法:本研究使用酶联免疫吸附测定(ELISA)检查了三个不同年龄段的韩国人的天花和水痘抗体。我们分析了2022年9月至2023年4月从韩国一家三级医院获得的56份血清。使用酶联免疫吸附测定法测量了针对天花病毒蛋白(天花细胞因子反应修饰蛋白B)和MPXV(A29)的抗体的血浆水平。
结果:40岁以上参与者的血浆样本对病毒抗原的反应性高于年轻参与者。此外,在整个血清中,两种不同病毒的抗体阳性呈强正相关。
结论:40岁的参与者中存在低抗体水平可能会阻碍他们防御OPXV的能力。因此,必须实施有效的公共卫生措施,以减轻OPXV在社区内的传播。这些发现是制定有效防治水痘策略的基本信息,特别是在病毒不流行的地区。