Abstract：
Rinse-off cosmetic products, primarily shampoos, are frequently implicated in the onset of allergic contact dermatitis (ACD) caused by alkyl glucosides (AGs). AGs are increasingly popular surfactants and known contact allergens. Glucoside-induced ACD was most frequently observed with shampoos and skin-cleansing products in both consumer and occupational settings. Thereby, studies have shown that atopic individuals are the most susceptible to ACD. Also, several investigations have indicated that individuals with sensitive skin might be more prone to skin allergies. This is why the presence of AGs was investigated in shampoos and body cleansers marketed as hypoallergenic or for sensitive skin. For this purpose, the website of Amazon.com was surveyed. Four groups of cosmetics were obtained by using the following keywords: \"hypoallergenic shampoo for adults,\" \"sensitive skin shampoo for adults,\" \"hypoallergenic body cleanser for adults,\" and \"sensitive skin body cleanser for adults.\" The first 30 best-selling cosmetics in each group were investigated for the presence of AGs, by analyzing the product information pages. The results showed that as much as 56.7% of hypoallergenic shampoos contained AGs, as ingredients, whereas the percentage was somewhat lower for other product categories. Even though decyl and lauryl glucoside were nearly ubiquitously used AGs in cosmetics over the past decade, the most commonly present AG in our analysis was coco-glucoside. The results of this study indicated a necessity to include coco-glucoside in the baseline series of patch testing allergens. Industry, regulators, and healthcare providers should be made aware of the frequent presence of AGs in rinse-off cosmetic products marketed as hypoallergenic or for sensitive skin to ensure the safety and well-being of consumers and patients.
摘要：
冲洗掉的化妆品，主要是洗发水,通常与烷基葡糖苷（AG）引起的过敏性接触性皮炎（ACD）的发作有关。AG是越来越受欢迎的表面活性剂和已知的接触过敏原。在消费者和职业环境中，洗发水和皮肤清洁产品最常观察到葡萄糖苷诱导的ACD。因此，研究表明，特应性个体最容易患ACD。此外，几项调查表明，皮肤敏感的人可能更容易发生皮肤过敏。这就是为什么在作为低过敏性或敏感皮肤销售的洗发水和身体清洁剂中研究AG的存在的原因。为此,对Amazon.com的网站进行了调查。通过使用以下关键字获得了四组化妆品：“成人低过敏性洗发水，“\”成人敏感皮肤洗发水，\“\”成人低过敏性身体清洁剂，\"和\"成人敏感皮肤身体清洁剂。“对每组前30种最畅销的化妆品进行了AG存在的调查，通过分析产品信息页面。结果显示，高达56.7%的低过敏性洗发水含有AG，作为成分，而其他产品类别的百分比略低。尽管在过去的十年中，癸基和月桂基葡萄糖苷几乎普遍用于化妆品中，我们分析中最常见的AG是可可葡糖苷.这项研究的结果表明，有必要在基线系列的贴片测试过敏原中包括可可葡糖苷。工业,监管者,和医疗保健提供者应该意识到在作为低过敏性或敏感皮肤销售的冲洗化妆品中经常存在AG，以确保消费者和患者的安全和福祉。
