皮炎是世界上最常见的皮肤病之一。特应性皮炎(AD)和接触性皮炎(CD)是其两种主要类型。很少有研究关注液体摄入量与皮炎之间的因果关系。孟德尔随机化(MR),这项研究调查了酒精的潜在因果关系,咖啡,茶,和水的摄入量对AD和CD的风险。
■利用遗传变异作为工具变量(IV),我们基于UKBiobank和FinnGenr9联盟的数据进行了双样本MR分析.液体摄入量分为酒精,咖啡,茶,和水的摄入量。通过逆方差加权(IVW)分析因果关系估计,MR-Egger,和加权中位数方法。Cochran\'sQ,MR-Egger截获,进行MR-PRESSO测试以评估潜在的异质性和多效性。
■水摄入量对CD风险升高具有显著的因果效应(IVWOR=2.92,95%CI:1.58-5.41,p=<0.01)。咖啡摄入与CD风险增加相关(IVWOR=2.16,95%CI:1.19-3.91,p=0.01)。相反,茶摄入对AD风险具有保护作用(IVWOR=0.71,95%CI:0.56-0.91,p=<0.01)。
■这项MR研究表明,水和咖啡的摄入可能与CD风险升高有关,而茶的摄入可能对AD风险有潜在的缓解作用。改变液体摄入模式可能是预防皮炎的一种有针对性的方法,强调需要额外的纵向研究来验证和扩展这些发现。
UNASSIGNED: Dermatitis is one of the most common skin disorders across the world. Atopic dermatitis (AD) and contact dermatitis (CD) are its two primary types. Few studies have focused on the causal relationship between fluid intake and dermatitis. With an Mendelian Randomization (MR), this study investigated the potential causal effects of alcohol, coffee, tea, and water intake on the risk of AD and CD.
UNASSIGNED: Utilizing genetic variants as instrumental variables (IVs), a two-sample MR analysis was implemented based on data from the UK Biobank and FinnGen r9 consortium. Fluid intake was categorized into alcohol, coffee, tea, and water intake. Causal estimates were analyzed through Inverse Variance Weighted (IVW), MR-Egger, and weighted median methods. Cochran\'s Q, MR-Egger intercept, and MR-PRESSO tests were conducted to assess potential heterogeneity and pleiotropy.
UNASSIGNED: Water intake exhibited a significant causal effect on raised CD risk (IVW OR = 2.92, 95% CI: 1.58-5.41, p = <0.01). Coffee intake was associated with increased CD risk (IVW OR = 2.16, 95% CI: 1.19-3.91, p = 0.01). Conversely, tea intake demonstrated a protective effect on AD risk (IVW OR = 0.71, 95% CI: 0.56-0.91, p = <0.01).
UNASSIGNED: This MR study suggests a potential association where water and coffee intake may be linked to an elevated risk of CD, while tea intake may potentially have a mitigating effect on AD risk. Modifying fluid intake patterns could be a targeted approach for dermatitis prevention, emphasizing the need for additional longitudinal studies to validate and expand upon these findings.