PDF(Pubmed)
Abstract：
UNASSIGNED: Obesity is characterized by an imbalance between energy intake and expenditure, leading to the excessive accumulation of triglycerides in adipose tissue.
UNASSIGNED: This study investigated the potential of Oxylia to prevent obesity in mice fed with a high-fat diet (HFD).
UNASSIGNED: C57BL/6J mice were fed with one of the following five diets - AIN93G normal diet (normal control), 60% (HFD; control), HFD containing metformin at 40 mg/kg body weight (b.w.) (Met; positive control), HFD containing Oxylia at 30 mg/kg b.w. (O30), or HFD containing Oxylia at 60 mg/kg b.w. (O60) - for 15 weeks.
UNASSIGNED: Mice under an HFD supplemented with Oxylia had decreased body weight gain, adipose tissue weight, and adipose tissue mass. In addition, triglyceride (TG), total cholesterol, and VLDL/LDL cholesterol levels were lower in the O60 groups than in the HFD-fed control group. Moreover, Oxylia supplementation decreased the expression of adipogenesis-related mRNAs and lipogenesis-related proteins while increasing the expression of lipolysis-related proteins in white adipose tissue and thermogenesis-related proteins in brown adipose tissue.
UNASSIGNED: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.
UNASSIGNED: This study investigated the potential of Oxylia to prevent obesity in mice fed with a high-fat diet (HFD).
UNASSIGNED: C57BL/6J mice were fed with one of the following five diets - AIN93G normal diet (normal control), 60% (HFD; control), HFD containing metformin at 40 mg/kg body weight (b.w.) (Met; positive control), HFD containing Oxylia at 30 mg/kg b.w. (O30), or HFD containing Oxylia at 60 mg/kg b.w. (O60) - for 15 weeks.
UNASSIGNED: Mice under an HFD supplemented with Oxylia had decreased body weight gain, adipose tissue weight, and adipose tissue mass. In addition, triglyceride (TG), total cholesterol, and VLDL/LDL cholesterol levels were lower in the O60 groups than in the HFD-fed control group. Moreover, Oxylia supplementation decreased the expression of adipogenesis-related mRNAs and lipogenesis-related proteins while increasing the expression of lipolysis-related proteins in white adipose tissue and thermogenesis-related proteins in brown adipose tissue.
UNASSIGNED: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.
摘要：
■肥胖的特征是能量摄入和消耗之间的不平衡，导致脂肪组织中甘油三酯的过度积累。
■这项研究研究了Oxylia预防高脂饮食（HFD）喂养的小鼠肥胖的潜力。
■C57BL/6J小鼠饲喂以下五种饮食之一-AIN93G正常饮食（正常对照），60%(HFD;对照),HFD含二甲双胍40mg/kg体重(b.w.)(Met;阳性对照),HFD含有30毫克/千克b.w.（O30）的Oxylia，或含有60mg/kgb.w.（O60）的Oxylia的HFD-持续15周。
■接受补充有Oxylia的HFD的小鼠体重增加减少，脂肪组织重量,和脂肪组织质量。此外,甘油三酯（TG），总胆固醇,O60组的VLDL/LDL胆固醇水平低于HFD喂养的对照组。此外，补充羟色胺可降低脂肪生成相关mRNA和脂肪生成相关蛋白的表达，同时增加白色脂肪组织中脂解相关蛋白和棕色脂肪组织中产热相关蛋白的表达。
■这些发现表明，Oxylia具有作为预防和治疗肥胖和相关代谢紊乱的功能性食品成分的潜力。
■这项研究研究了Oxylia预防高脂饮食（HFD）喂养的小鼠肥胖的潜力。
■C57BL/6J小鼠饲喂以下五种饮食之一-AIN93G正常饮食（正常对照），60%(HFD;对照),HFD含二甲双胍40mg/kg体重(b.w.)(Met;阳性对照),HFD含有30毫克/千克b.w.（O30）的Oxylia，或含有60mg/kgb.w.（O60）的Oxylia的HFD-持续15周。
■接受补充有Oxylia的HFD的小鼠体重增加减少，脂肪组织重量,和脂肪组织质量。此外,甘油三酯（TG），总胆固醇,O60组的VLDL/LDL胆固醇水平低于HFD喂养的对照组。此外，补充羟色胺可降低脂肪生成相关mRNA和脂肪生成相关蛋白的表达，同时增加白色脂肪组织中脂解相关蛋白和棕色脂肪组织中产热相关蛋白的表达。
■这些发现表明，Oxylia具有作为预防和治疗肥胖和相关代谢紊乱的功能性食品成分的潜力。
