Abstract：
Pharmacological studies have consistently shown memory retrieval impairment after administration of cortisol, particularly pronounced for emotional laboratory material (i.e. list of emotional words). However, it is unclear how pharmacological elevation of cortisol affects memory retrieval of ecologically-relevant emotional material (i.e. similar to a newspaper article about an emotional event). In the present study, we aimed to explore whether cortisol administration affects the recall of ecologically-relevant emotional and neutral material, and when memory retrieval occurs after a longer delay (105 min). In this double-blind, pseudo-randomized, placebo-control study, 79 participants learned a negative text and a neutral text. Twenty-four hours later, they were administrated either 10 mg of hydrocortisone or placebo. After 105 min, participants engaged in free recall of both texts. The group with cortisol administration showed significantly reduced free recall compared to the placebo group. Interestingly, this memory retrieval impairment was driven by significantly lower recall after cortisol vs. placebo administration for neutral texts, but not negative texts. The current finding suggests that cortisol administration impairs neutral ecologically-relevant material while leaving emotional material unaffected. These divergent findings, compared to existing literature, emphasize the necessity of employing more ecologically validated material to gain a more comprehensive understanding of the intricate interplay between cortisol administration and memory for ecological material.
摘要：
药理学研究一致表明，服用皮质醇后记忆恢复受损，对于情感实验室材料（即情感单词列表）特别明显。然而,目前尚不清楚皮质醇的药理学升高如何影响生态相关情绪材料的记忆检索(即类似于报纸上关于情绪事件的文章).在本研究中,我们旨在探讨皮质醇管理是否会影响生态相关的情绪和中性材料的召回，以及在更长的延迟（105分钟）后发生内存检索时。在这个双盲中，伪随机，安慰剂对照研究，79名参与者学习了否定文本和中性文本。二十四小时后,他们服用了10mg氢化可的松或安慰剂。105分钟后，参与者参与自由召回这两个文本。与安慰剂组相比，使用皮质醇的组显示出明显减少的自由回忆。有趣的是,这种记忆恢复障碍是由皮质醇与中性文本的安慰剂管理，但不是负面文本。当前的发现表明，皮质醇管理会损害与生态相关的中性物质，同时使情感物质不受影响。这些不同的发现，与现有文献相比，强调使用更多生态验证材料的必要性，以更全面地了解皮质醇管理与生态材料记忆之间的复杂相互作用。
