PDF(Pubmed)
Abstract：
The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption safety remains inadequately addressed. In this work, commercially available Arthrospira (Spirulina) platensis Gomont and/or Fucus vesiculosus L. supplements showed moderate capacity to inhibit the activity of carbohydrate-metabolizing enzymes, and to scavenge biologically relevant reactive species. IC25 values varying between 4.54 ± 0.81 and 66.73 ± 5.91 µg of dry extract/mL and between 53.74 ± 8.42 and 1737.96 ± 98.26 µg of dry extract/mL were obtained for α-glucosidase and aldose reductase, respectively. A weaker effect towards α-amylase activity was observed, with a maximum activity of the extracts not going beyond 33%, at the highest concentrations tested. Spirulina extracts showed generally better effects than those from F. vesiculosus. Similar results were observed concerning the antiradical capacity. In a general way, the extracts were able to intercept the in vitro-generated reactive species nitric oxide (•NO) and superoxide anion (O2•-) radicals, with better results for O2•-scavenging with the spirulina samples (IC25 values of 67.16 and 122.84 µg of dry extract/mL). Chemically, similar pigment profiles were observed between spirulina supplements and the authenticated counterpart. However, fucoxanthin, the chemotaxonomic marker of brown seaweeds, was not found in F. vesiculosus samples, pointing to the occurrence of a degradation phenomenon before, during, or after raw material processing. Our findings can contribute to providing data to allow regulatory entities (e.g., EFSA and FDA) to better rule these products in a way that can benefit society.
摘要：
肥胖的全球患病率影响了超过6亿成年人。成功控制体重可有效降低患慢性病的风险，但保持长期减肥仍然是一个挑战。尽管有基于藻类的补充剂声称有助于减肥，明显缺乏支持其有效性的科学证据，他们的常规消费安全问题仍未得到充分解决。在这项工作中,市售的节旋藻（螺旋藻）PlatensisGomont和/或FucusvesiculosusL.补充剂显示出适度的抑制碳水化合物代谢酶活性的能力，并清除生物相关的反应性物种。对于α-葡萄糖苷酶和醛糖还原酶，获得的IC25值在4.54±0.81和66.73±5.91µg干提取物/mL之间以及在53.74±8.42和1737.96±98.26µg干提取物/mL之间变化，分别。观察到对α-淀粉酶活性的较弱影响，提取物的最大活性不超过33%，在测试的最高浓度。螺旋藻提取物总体上显示出比膀胱螺旋藻更好的效果。关于抗自由基能力观察到类似的结果。总的来说，提取物能够拦截体外产生的反应性物种一氧化氮（•NO）和超氧阴离子（O2•-）自由基，用螺旋藻样品清除O2的结果更好（IC25值为67.16和122.84µg干提取物/mL）。化学上,在螺旋藻补充剂和经过认证的对应物之间观察到相似的色素分布。然而,岩藻黄质,棕色海藻的化学分类标记，在膀胱螺旋杆菌样本中没有发现,指向之前发生的退化现象，during,或经过原材料加工。我们的发现有助于提供数据，允许监管实体(例如，EFSA和FDA）以有利于社会的方式更好地统治这些产品。
