PDF(Pubmed)
Abstract：
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca2+ homeostasis, which are closely associated with the occurrence and development of epilepsy. In this review, we summarize the potential contributions of TSP-1 to epilepsy development.
摘要：
癫痫是由兴奋性和抑制性网络之间的不平衡引起的不受控制的神经元兴奋过度引起的神经网络障碍。突触发生异常在过度兴奋网络的形成中起着至关重要的作用。最近的证据已经证实，血小板反应蛋白-1（TSP-1），主要由星形胶质细胞分泌，是癫痫发生过程中调节突触发生的关键细胞因子。此外，许多研究报告说，TSP-1也参与其他过程，比如血管生成，神经炎症，和调节Ca2+稳态，与癫痫的发生发展密切相关。在这次审查中,我们总结了TSP-1对癫痫发展的潜在贡献.
