{Reference Type}: Journal Article
{Title}: The Contributions of Thrombospondin-1 to Epilepsy Formation.
{Author}: Cheng Y;Zhai Y;Yuan Y;Wang Q;Li S;Sun H;
{Journal}: Neurosci Bull
{Volume}: 40
{Issue}: 5
{Year}: 2024 May 26
{Factor}: 5.271
{DOI}: 10.1007/s12264-024-01194-2
{Abstract}: Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca2+ homeostasis, which are closely associated with the occurrence and development of epilepsy. In this review, we summarize the potential contributions of TSP-1 to epilepsy development.