关键词: Antiplatelet aggregation activities Ginkgo biloba Ginkgolides

Mesh : Ginkgo biloba / chemistry Molecular Structure Ginkgolides / pharmacology isolation & purification chemistry Platelet Aggregation Inhibitors / pharmacology isolation & purification chemistry Phytochemicals / pharmacology isolation & purification Animals Platelet Aggregation / drug effects

来  源:   DOI:10.1016/j.fitote.2024.105915

Abstract:
Four undescribed ginkgolides, including two rare sesquiterpene ginkgolides (compounds 1 and 2) and two diterpenoid ginkgolides (compounds 3 and 4), were isolated from Ginkgo biloba L. The structures of these four ginkgolides were identified based on extensive spectroscopic analysis, DP4+ probability analysis and X-ray diffraction. Compounds 1 and 2 exhibited excellent antiplatelet aggregation activities with IC50 values of 1.20 ± 0.25 and 4.11 ± 0.34 μM, respectively.
摘要:
四种未描述的银杏内酯,包括两种稀有的倍半萜银杏内酯(化合物1和2)和两种二萜银杏内酯(化合物3和4),这四种银杏内酯的结构是基于广泛的光谱分析鉴定,DP4+概率分析和X射线衍射。化合物1和2表现出优异的抗血小板聚集活性,IC50值分别为1.20±0.25和4.11±0.34μM,分别。
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