{Reference Type}: Journal Article
{Title}: Ginkgolides with anti-PAF activity from Ginkgo biloba L.
{Author}: Zhang J;Chen S;Sun P;Liu Y;Jiang J;Guo C;Cheng J;Liu X;Zhang J;Chen C;Di J;Liu A;Xu Q;
{Journal}: Fitoterapia
{Volume}: 175
{Issue}: 0
{Year}: 2024 Jun 19
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2024.105915
{Abstract}: Four undescribed ginkgolides, including two rare sesquiterpene ginkgolides (compounds 1 and 2) and two diterpenoid ginkgolides (compounds 3 and 4), were isolated from Ginkgo biloba L. The structures of these four ginkgolides were identified based on extensive spectroscopic analysis, DP4+ probability analysis and X-ray diffraction. Compounds 1 and 2 exhibited excellent antiplatelet aggregation activities with IC50 values of 1.20 ± 0.25 and 4.11 ± 0.34 μM, respectively.