%0 Journal Article
%T Ginkgolides with anti-PAF activity from Ginkgo biloba L.
%A Zhang J
%A Chen S
%A Sun P
%A Liu Y
%A Jiang J
%A Guo C
%A Cheng J
%A Liu X
%A Zhang J
%A Chen C
%A Di J
%A Liu A
%A Xu Q
%J Fitoterapia
%V 175
%N 0
%D 2024 Jun 19
%M 38508499
%F 3.204
%R 10.1016/j.fitote.2024.105915
%X Four undescribed ginkgolides, including two rare sesquiterpene ginkgolides (compounds 1 and 2) and two diterpenoid ginkgolides (compounds 3 and 4), were isolated from Ginkgo biloba L. The structures of these four ginkgolides were identified based on extensive spectroscopic analysis, DP4+ probability analysis and X-ray diffraction. Compounds 1 and 2 exhibited excellent antiplatelet aggregation activities with IC50 values of 1.20 ± 0.25 and 4.11 ± 0.34 μM, respectively.