Abstract：
Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. Although anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promising means by which to enhance the global control of tropical infectious diseases; however, these have been difficult to develop, mostly because of the complex nature of the pathogen lifecycles. Here, we present recently developed vaccine candidates for five tropical infectious diseases in the form of a catalog that have either entered clinical trials or have been licensed for use. We deliberate on recently licensed dengue vaccines, provide evidence why combination vaccination could have a synergistic impact on schistosomiasis, critically appraise the value of typhoid conjugate vaccines, and discuss the potential of vaccines in the efforts to eliminate vivax malaria and hookworms.
摘要：
热带传染病给生活在发展中国家的人类造成了不可接受的疾病负担。虽然抗病原药物已被广泛使用,他们不断面临选择抵抗的威胁。疫苗提供了一种有希望的手段，可以加强对热带传染病的全球控制，但是这些很难发展，主要是由于病原体生命周期的复杂性。这里,我们以目录的形式介绍了最近开发的针对五种热带传染病的候选疫苗，已进入临床试验或已获得使用许可。我们研究了最近获得许可的登革热疫苗；提供了为什么联合疫苗接种可以对血吸虫病产生协同影响的证据；严格评估伤寒结合疫苗的价值；并讨论了疫苗在消除间日疟疾和钩虫的努力中的潜力。
