■本研究旨在确定流行病学,临床特征,以及成人广泛耐药伤寒沙门氏菌(XDR伤寒)感染的并发症。
■这项横断面研究招募了接受HayatabadMedicalComplex的经文化证实的XDR伤寒S.白沙瓦,2022年3月1日至9月10日。他们的人口特征,临床特征,治疗,并记录并发症。
■在84名患者中,68(80.9%)为男性。入选患者的平均年龄为25.2±11.3岁。入院时发热的平均持续时间为13.6±8.2天,分别。最常见的症状是稀便(n=25,29.8%)。大多数患者(n=69,82.1%)在住院前接受了经验性治疗。在研究期间,大多数患者(n=42,50%)接受了美罗培南以及美罗培南和阿奇霉素的组合(n=35,41.7%)。两种方案的退热时间相似。5例(6%)出现肠热并发症。参与者没有死亡。
■腹泻是XDR伤寒最常见的相关临床特征。大多数患者单独接受美罗培南或与阿奇霉素联合使用,退热时间相当。大多数患者恢复顺利,研究参与者中没有死亡。
UNASSIGNED: This study aimed to determine the epidemiology, clinical features, and complications of extensively drug-resistant Salmonella typhi (XDR S. typhi) infection in adults.
UNASSIGNED: This cross-sectional study enrolled adults with culture-proven XDR S. typhi admitted to Hayatabad Medical Complex, Peshawar from 1st March to 10th September 2022. Their demographic characteristics, clinical features, treatment, and complications were recorded.
UNASSIGNED: Out of 84 patients, 68 (80.9%) were male. The mean age of enrolled patients was 25.2 ± 11.3 years. The mean duration of fever at the time of admission was 13.6 ± 8.2 days, respectively. The most common symptom was loose stools (n=25, 29.8%). Most of the patients (n=69, 82.1%) had received empirical treatment before hospitalization. The majority of the patients (n=42, 50%) received meropenem and a combination of meropenem and azithromycin (n=35, 41.7%) during the study. The time to defervescence for both regimens was similar. Five patients (6%) developed complications of enteric fever. There was no mortality among the participants.
UNASSIGNED: Diarrhea was the most common associated clinical feature in XDR typhoid fever. Most of the patients received meropenem alone or in combination with azithromycin with a comparable time to defervescence. The majority of the patients recovered uneventfully and there was no mortality among the study participants.