PDF(Pubmed)
Abstract：
OBJECTIVE: We evaluate morphological and functional correlations in patients with acute central serous chorioretinopathy (CSC).
METHODS: A prospective study was conducted on 50 patients with an acute CSC episode lasting less than 3 months. At baseline, assessments included optical coherence tomography (OCT), best-corrected visual acuity (BCVA), contrast sensitivity (CS), microperimetry (MP), and multifocal electroretinography (mfERG). A correlation analysis between OCT morphological parameters (maximal subretinal fluid height (SRF), central retinal thickness (CRT), and macular volume (MV)) and functional parameters was conducted on the affected eye for each patient.
RESULTS: Among the morphological parameters, SRF showed the strongest correlations with functional parameters (r absolute value range = 0.10-0.70). Weak correlations were observed between BCVA and morphological parameters (r absolute value range = 0.14-0.26). Average retinal sensitivity (MP-A) was the functional parameter displaying the most robust negative correlation with morphological parameters (r absolute value range = 0.61-0.70). In contrast, average contrast sensitivity (CS-A) and mfERG average amplitude density in the first (mfERG-A1) and second (mfERG-A2) ring showed weak to moderate (r absolute value range = 0.35-0.56) yet statistically significantly nonzero correlations.
CONCLUSIONS: SRF and CRT could serve as the most representative morphological proxies for visual function deficit in acute CSC patients. Retinal sensitivity, as measured by MP, may be superior to BCVA in clinical research studies or when an in-depth visual function evaluation is needed.
METHODS: A prospective study was conducted on 50 patients with an acute CSC episode lasting less than 3 months. At baseline, assessments included optical coherence tomography (OCT), best-corrected visual acuity (BCVA), contrast sensitivity (CS), microperimetry (MP), and multifocal electroretinography (mfERG). A correlation analysis between OCT morphological parameters (maximal subretinal fluid height (SRF), central retinal thickness (CRT), and macular volume (MV)) and functional parameters was conducted on the affected eye for each patient.
RESULTS: Among the morphological parameters, SRF showed the strongest correlations with functional parameters (r absolute value range = 0.10-0.70). Weak correlations were observed between BCVA and morphological parameters (r absolute value range = 0.14-0.26). Average retinal sensitivity (MP-A) was the functional parameter displaying the most robust negative correlation with morphological parameters (r absolute value range = 0.61-0.70). In contrast, average contrast sensitivity (CS-A) and mfERG average amplitude density in the first (mfERG-A1) and second (mfERG-A2) ring showed weak to moderate (r absolute value range = 0.35-0.56) yet statistically significantly nonzero correlations.
CONCLUSIONS: SRF and CRT could serve as the most representative morphological proxies for visual function deficit in acute CSC patients. Retinal sensitivity, as measured by MP, may be superior to BCVA in clinical research studies or when an in-depth visual function evaluation is needed.
摘要：
目的：我们评估急性中心性浆液性脉络膜视网膜病变（CSC）患者的形态学和功能相关性。
方法：对50例持续少于3个月的急性CSC患者进行了前瞻性研究。在基线,评估包括光学相干断层扫描（OCT），最佳矫正视力（BCVA），对比敏感度（CS），显微视野（MP），多焦视网膜电图（mfERG）。OCT形态学参数(最大视网膜下液高度(SRF),中央视网膜厚度（CRT），和黄斑体积（MV））和功能参数在每个患者的受影响的眼睛进行。
结果：在形态参数中，SRF与功能参数的相关性最强（r绝对值范围=0.10-0.70）。观察到BCVA与形态参数之间的相关性较弱（r绝对值范围=0.14-0.26）。平均视网膜灵敏度（MP-A）是功能参数，与形态参数表现出最强烈的负相关（r绝对值范围=0.61-0.70）。相比之下,第一环(mfERG-A1)和第二环(mfERG-A2)的平均对比敏感度(CS-A)和mfERG平均振幅密度显示弱-中等(r绝对值范围=0.35-0.56),但具有统计学显著的非零相关性.
结论：SRF和CRT可以作为急性CSC患者视功能缺损的最具代表性的形态学指标。视网膜敏感性,以MP衡量，在临床研究或需要深入的视觉功能评估时，可能优于BCVA。
方法：对50例持续少于3个月的急性CSC患者进行了前瞻性研究。在基线,评估包括光学相干断层扫描（OCT），最佳矫正视力（BCVA），对比敏感度（CS），显微视野（MP），多焦视网膜电图（mfERG）。OCT形态学参数(最大视网膜下液高度(SRF),中央视网膜厚度（CRT），和黄斑体积（MV））和功能参数在每个患者的受影响的眼睛进行。
结果：在形态参数中，SRF与功能参数的相关性最强（r绝对值范围=0.10-0.70）。观察到BCVA与形态参数之间的相关性较弱（r绝对值范围=0.14-0.26）。平均视网膜灵敏度（MP-A）是功能参数，与形态参数表现出最强烈的负相关（r绝对值范围=0.61-0.70）。相比之下,第一环(mfERG-A1)和第二环(mfERG-A2)的平均对比敏感度(CS-A)和mfERG平均振幅密度显示弱-中等(r绝对值范围=0.35-0.56),但具有统计学显著的非零相关性.
结论：SRF和CRT可以作为急性CSC患者视功能缺损的最具代表性的形态学指标。视网膜敏感性,以MP衡量，在临床研究或需要深入的视觉功能评估时，可能优于BCVA。
