■探讨先天性膈疝(CDH)患儿氧合指数(OI)与氧饱和指数(OSI)的关系,在出生后的头24小时内以及在手术干预之前存活下来的人的长期观察中。
■对单个III级新生儿重症监护病房的CDH病例进行了7年的回顾性回顾。使用Spearman的rho相关系数评估OI-OSI对的各种组合的相关性。此外,在最初的24小时内,录取之间的相关性(第一),最好(最低),最高,并确定平均OI和OSI值。使用曲线下面积(AUC)分析评估前24小时氧和氧饱和度指数对死亡率和其他不良后果的预测能力。
■37例CDH患儿纳入分析。在所有OI/OSI对(2,289)(Spearman\srho=0.843)之间观察到了很强的相关性,导管后OI/OSI匹配对(1,232对)(Spearman'srho=0.835)和导管后OI和PrecordalOSI不匹配对(1,057对)(Spearman'srho=0.852)。使用所有配对的回归方程,匹配和不匹配的OI/OSI对,我们推断,对于临床相关的OI阈值10,15,20和40,相应的OSI值分别为5,8,11和23.此外,在最初的24小时内,OI/OSI之间存在很强的相关性:入院时(斯皮尔曼的rho=0.783),最佳OI/OSI(斯皮尔曼的rho=0.848),和最高的OI/OSI(斯皮尔曼的rho=0.921)。在平均OI/OSI与0.928的Spearmanrho之间观察到最稳健的相关性。首先(AUC=0.849),最好(AUC=0.927),最高(AUC=0.942)和第1天平均OI(AUC=0.946)均可预测死亡率.同样,首先(AUC=1.00),最好(AUC=0.989),第1天最高(AUC=1.00)和平均OSI(AUC=0.978)均可预测死亡率.除入院OSI(AUC=0.683)外,第1天的所有OI和OSI均可预测肺动脉高压。此外,除第1天最佳OI(AUC=0.674)外,前24小时的所有OI和OSI指数均可预测是否需要抢救HFOV.
■CDH患儿的OI与OSI有很强的相关性。最初24小时的氧合指数和OSI可预测CDH婴儿的死亡率和其他不良结局。
UNASSIGNED: To explore the relationship between Oxygenation Index (OI) and Oxygen Saturation Index (OSI) among infants with Congenital Diaphragmatic Hernia (CDH), both within the first 24 h after birth and in extended observations in those who survived until their surgical intervention.
UNASSIGNED: Seven- years retrospective review of CDH cases at a single Level III neonatal intensive care unit. The
correlations of various combinations of OI-OSI pairs were assessed using the Spearman\'s rho Correlation Coefficient. Additionally, during the initial 24 h, the
correlations between admission (first), best (lowest), highest, and mean OI and OSI values were determined. The predictive ability of the first 24 h oxygen and oxygen saturation indices for mortality and other adverse outcomes were assessed using the Area Under the Curve (AUC) analysis.
UNASSIGNED: Thirty-seven infants with CDH were included in the analysis. A strong correlation was observed between all pairs of OI/OSI (2,289) (Spearman\'s rho = 0.843), matched pairs of Postductal OI/OSI (1,232 pairs) (Spearman\'s rho = 0.835) and the unmatched pairs of Postductal OI and Preductal OSI (1,057 pairs) (Spearman\'s rho = 0.852). Using the regression equations for all pairs, matched and unmatched OI/OSI pairs, we deduced that for clinically pertinent OI thresholds of 10, 15, 20 and 40, the corresponding OSI values were 5, 8, 11, and 23, respectively. Furthermore, in the first 24 h, strong
correlations were evident between OI/OSI: at admission (Spearman\'s rho = 0.783), best OI/OSI (Spearman\'s rho = 0.848), and highest OI/OSI (Spearman\'s rho = 0.921). The most robust correlation was observed between the mean OI/OSI with a Spearman\'s rho of 0.928. First (AUC = 0.849), best (AUC = 0.927), highest (AUC = 0.942) and mean day 1 OI (AUC = 0.946) were all predictive of mortality. Similarly, first (AUC = 1.00), best (AUC = 0.989), highest (AUC = 1.00) and the mean OSI in day 1 (AUC = 0.978) were all predictive of mortality. All of the OIs and OSIs in day 1 except for the admission OSI (AUC = 0.683) were predictive of pulmonary hypertension. Additionally, all of OI and OSI indices in the first 24-hour except for the best day 1 OI (AUC = 0.674) were predictive of the need for rescue HFOV.
UNASSIGNED: There were a strong correlation between the OI and OSI in infants with CDH. Oxygenation indices and OSI in the first 24 h were predictive of mortality and other adverse outcomes in infants with CDH.