Abstract：
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing social cues and influencing social behaviors. Furthermore, combining these tools with translationally relevant behavioral paradigms has also provided novel insights into the PFC neural mechanisms that may contribute to social deficits in various psychiatric disorders. This review highlights findings from the past decade that have shed light on the PFC cell types and neural circuits that support social information processing and distinct aspects of social behavior, including social interactions, social memory, and social dominance. We also explore how the PFC contributes to social deficits in rodents induced by social isolation, social fear conditioning, and social status loss. These studies provide evidence that the PFC uses both overlapping and unique neural mechanisms to support distinct components of social cognition. Furthermore, specific PFC neural mechanisms drive social deficits induced by different contexts.
摘要：
前额叶皮层（PFC）是众所周知的大脑的执行中心，结合内部状态和目标来执行有目的的行为，包括社会行动。随着监测和操纵啮齿动物神经活动的工具的进步，在了解PFC内的特定细胞类型和神经回路方面已经取得了实质性进展，这对于处理社会线索和影响社会行为至关重要。此外，将这些工具与翻译相关的行为范式相结合，也为PFC神经机制提供了新的见解，这些机制可能导致各种精神疾病的社会缺陷。这篇综述强调了过去十年的发现，这些发现揭示了支持社会信息处理和社会行为不同方面的PFC细胞类型和神经回路。包括社会互动，社会记忆,社会支配地位。我们还探讨了PFC如何导致由社会隔离引起的啮齿动物的社会缺陷，社会恐惧条件，社会地位的丧失。这些研究提供了证据，表明PFC使用重叠和独特的神经机制来支持社会认知的不同组成部分。Further,特定的PFC神经机制驱动由不同环境引起的社会缺陷。
