Abstract：
In order to improve the living standards of diabetes patients and reduce the negative health effects of this disease, the medical community has been actively searching for more effective treatments. In recent years, an artificial pancreas has emerged as an important approach to managing diabetes. Despite these recent advances, meeting the requirements for miniaturized size, accurate sensing and large-volume pumping capability remains a great challenge. Here, we present a novel miniaturized artificial pancreas based on a long microtube sensor integrated with an ultrasonic pump. Our device meets the requirements of achieving both accurate sensing and high pumping capacity. The artificial pancreas is constructed based on a long microtube that is low cost, painless and simple to operate, where the exterior of the microtube is fabricated as a glucose sensor for detecting diabetes and the interior of the microtube is used as a channel for delivering insulin through an ultrasonic pump. This work successfully achieved closed-loop control of blood glucose and treatment of diabetes in rats. It is expected that this work can open up new methodologies for the development of microsystems, and advance the management approach for diabetes patients.
摘要：
为了提高糖尿病患者的生活水平，减少这种疾病对健康的负面影响，医学界一直在积极寻找更有效的治疗方法。近年来,人工胰腺已成为治疗糖尿病的重要方法。尽管最近取得了这些进展，满足小型化尺寸的要求，准确的传感和大容量抽水能力仍然是一个巨大的挑战。这里,我们提出了一种新颖的小型化人工胰腺，其基础是与超声波泵集成的长微管传感器。我们的设备满足实现精确传感和高泵送能力的要求。人造胰腺是基于低成本的长微管构建的，无痛且操作简单，其中微管的外部被制造为用于检测糖尿病的葡萄糖传感器,并且微管的内部被用作用于通过超声泵递送胰岛素的通道。这项工作成功地实现了对大鼠血糖的闭环控制和糖尿病的治疗。预计这项工作可以为微系统的开发开辟新的方法，并提出糖尿病患者的管理方法。
