Abstract：
The telencephalon of ray-finned fishes undergoes eversion, which is very different to the evagination that occurs in most other vertebrates. Ventricle morphogenesis is key to build an everted telencephalon. Thus, here we use the apical marker zona occludens 1 to understand ventricle morphology, extension of the tela choroidea and the eversion process during early telencephalon development of four teleost species: giant danio (Devario aequipinnatus), blind cavefish (Astyanax mexicanus), medaka (Oryzias latipes), and paradise fish (Macroposus opercularis). In addition, by using immunohistochemistry against tubulin and calcium-binding proteins, we analyze the general morphology of the telencephalon, showing changes in the location and extension of the olfactory bulb and other telencephalic regions from 2 to 5 days of development. We also analyze the impact of abnormal eye and telencephalon morphogenesis on eversion, showing that cyclops mutants do undergo eversion despite very dramatic abnormal eye morphology. We discuss how the formation of the telencephalic ventricle in teleost fish, with its characteristic shape, is a crucial event during eversion.
摘要：
鱼翅的端脑经历外翻，这与大多数其他脊椎动物的逃避非常不同。心室形态发生是建立外翻端脑的关键。因此，在这里，我们使用顶端标记带闭塞1来了解心室形态，在四个硬骨鱼物种的早期端脑发育过程中，telachoroidea的扩展和外翻过程：巨型danio（Devarioaequipinnatus），盲洞穴鱼（墨西哥Astyanaxmexicanus），medaka(Oryziaslatipes)，和天堂鱼（Macroposusopercularis）。此外,通过对微管蛋白和钙结合蛋白的免疫组织化学，我们分析了端脑的一般形态，显示嗅球和其他端脑区域在发育2到5天的位置和延伸的变化。我们还分析了异常眼和端脑形态发生对外翻的影响，表明尽管眼睛形态非常异常，但独眼突变体确实会发生外翻。我们讨论了硬骨鱼的端脑心室的形成，以其特有的形状，是外翻期间的一个重要事件。
