Abstract：
Methiopropamine or 1-(thiophen-2-yl)-2-methylaminopropane (MPA) is a thiophene ring-based structural analogue of methamphetamine, first synthesized in 1942 but become popular when it started to be available for purchase on websites selling \'legal highs\' since 2010. While it is legally controlled in many countries, it remains readily accessible and frequently encountered in recreational settings. The growing prevalence of MPA use results in new therapeutic challenges. Relatively few studies have focused on its pharmacodynamics and pharmacokinetics, making it important to better understand its potential risks and harmful effects in humans in terms of its toxicity. This review provides a comprehensive profiling of MPA toxicological properties, including its chemical properties, analytical methods, prevalence, patterns of use, and legal status. Additionally, it discusses the drug\'s effects on the central nervous system, its potential for addiction, and its adverse physical and mental health effects. Improving the understanding of safety aspects of MPA and how it imposes health threats for public health will guide the development of therapeutic approach of its intoxication and guide the authorities in deciding its legal status.
摘要：
甲基丙胺或1-（噻吩-2-基）-2-甲基氨基丙烷（MPA）是甲基苯丙胺的基于噻吩环的结构类似物，1942年首次合成，但自2010年以来，当它开始在销售“合法高点”的网站上购买时，它变得很受欢迎。虽然它在许多国家受到法律控制，它仍然很容易获得，并经常在娱乐环境中遇到。MPA使用的日益普及导致新的治疗挑战。相对较少的研究集中在其药效学和药代动力学，因此，就其毒性而言，更好地了解其对人类的潜在风险和有害影响是很重要的。这篇综述提供了MPA毒理学特性的全面分析，包括它的化学性质，分析方法，患病率,使用模式，和法律地位。此外,它讨论了药物对中枢神经系统的影响，它可能上瘾，及其对身心健康的不利影响。提高对MPA安全方面的理解以及它如何对公共卫生造成健康威胁，将指导其中毒治疗方法的发展，并指导当局决定其法律地位。
