Newly Identified Mycobacterium africanum Lineage 10, Central Africa.

新鉴定的非洲分枝杆菌谱系 10 ， 中非。

• 影响指数: 16.126
• 发表时间: 2024 Oct
• 来源期刊: Emerg Infect Dis
• DOI: 10.3201/eid3003.231466
• PMID: 38407162
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Guyeux C,Senelle G,Le Meur A,Supply P,Gaudin C,Phelan JE,Clark TG,Rigouts L,de Jong B,Sola C,Refrégier G

关键词: Democratic Republic of the Congo; L10; Mycobacterium tuberculosis; TB; bacteria; central Africa; lineage 10; pathogen diversification; respiratory infections; tuberculosis and other mycobacteria; tuberculosis emergence

Mesh: Phylogeny; Biological Evolution; Mycobacterium / genetics; Software; Africa, Central / epidemiology

Abstract

Analysis of genome sequencing data from >100,000 genomes of Mycobacterium tuberculosis complex using TB-Annotator software revealed a previously unknown lineage, proposed name L10, in central Africa. Phylogenetic reconstruction suggests L10 could represent a missing link in the evolutionary and geographic migration histories of M. africanum.

摘要

使用TB-Annotator软件对来自超过100,000个结核分枝杆菌复合体基因组的基因组测序数据进行分析，揭示了以前未知的谱系，提议的名字L10，在非洲中部。系统发育重建表明L10可能代表非洲分枝杆菌进化和地理迁移历史中的缺失环节。