Abstract：
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently consumed by athletes to manage muscle soreness, expedite recovery, or improve performance. Despite the prevalence of NSAID use, their effects on muscle soreness and performance, particularly when administered prophylactically, remain unclear. This randomized, double-blind, counter-balanced, crossover study examined the effect of consuming a single dose of each of three NSAIDs (celecoxib, 200 mg; ibuprofen, 800 mg; flurbiprofen, 100 mg) or placebo 2 h before on muscle soreness and performance following an acute plyometric training session. Twelve healthy adults, aged 18-42 years, completed a standardized plyometric exercise session consisting of 10 sets of 10 repetitions at 40 % 1-repetition maximum (1RM) on a leg press device. During exercise, total work, rating of perceived exertion, and heart rate were measured. Maximum voluntary contraction force (MVC), vertical jump height, and muscle soreness were measured before exercise and 4-h and 24-h post-exercise. We found no significant differences in total work, heart rate, or rating of perceived exertion between treatments. Additionally, no significant differences in muscle soreness or vertical jump were observed between treatments. Ibuprofen and flurbiprofen did not prevent decrements in MVC, but celecoxib attenuated decreases in MVC 4-h post exercise (p < 0.05). This study suggests that athletes may not benefit from prophylactic ibuprofen or flurbiprofen treatment to prevent discomfort or performance decrements associated with exercise, but celecoxib may mitigate short-term performance decrements.
摘要：
非甾体抗炎药（NSAIDs）经常被运动员消耗以控制肌肉酸痛，加速恢复，或提高性能。尽管使用NSAID很普遍,它们对肌肉酸痛和表现的影响，特别是预防性施用时，仍然不清楚。这个随机的，双盲,平衡,交叉研究检查了单次服用三种非甾体抗炎药(塞来昔布，200毫克；布洛芬，800毫克；氟比洛芬，100mg）或安慰剂2小时前，在急性补全训练后的肌肉酸痛和表现。十二个健康的成年人，18-42岁,在压腿装置上完成了由10组10次重复组成的标准化强度训练，最大1次重复40％（1RM）。在锻炼过程中,总工作量,感知努力的评级，测量心率。最大自愿收缩力（MVC），垂直跳跃高度,运动前和运动后4小时和24小时测量肌肉酸痛。我们发现总工作量没有显着差异，心率,或对治疗之间感知到的劳累进行评级。此外,治疗之间的肌肉酸痛或垂直跳跃没有显着差异。布洛芬和氟比洛芬不能防止MVC的下降，但是塞来昔布在运动后4小时的MVC中减弱（p<0.05）。这项研究表明，运动员可能无法从预防性布洛芬或氟比洛芬治疗中受益，以防止与运动相关的不适或表现下降。但塞来昔布可能会减轻短期性能下降。
