Abstract：
Fourier-transform infrared (FTIR) spectroscopy using the IR Biotyper and core genome single nucleotide polymorphism (cgSNP) analysis were performed on 12 Legionella isolates associated with an outbreak at a spa house in Kanagawa Prefecture, Japan, and 3 non-outbreak isolates. The discriminative power of FTIR spectroscopy for 48-h incubation conditions of L. pneumophila in this outbreak was lower than cgSNP-based typing but higher than serogroup typing. FTIR spectroscopy could screen outbreak isolates from a group of genetically related isolates and may be useful as an initial typing method in Legionella outbreak investigations.
摘要：
使用IRBiotyper和核心基因组单核苷酸多态性（cgSNP）分析的傅立叶变换红外（FTIR）光谱对与神奈川县一家温泉屋爆发有关的12个军团菌分离株进行了分析，Japan,和3个非爆发分离株。在这次爆发中，对嗜肺乳杆菌48小时孵育条件的FTIR光谱的判别能力低于基于cgSNP的分型，但高于血清群分型。FTIR光谱可以从一组遗传相关的分离株中筛选爆发分离株，并可用作军团菌爆发调查的初始分型方法。
