背景:傅立叶变换红外(FTIR)光谱已成为医学研究中强大的分析工具,提供生物样品的分子组成的非侵入性和精确的检查。这篇综述的主要目的是强调FTIR光谱在医学研究中的益处,强调其描绘分子指纹并协助鉴定生物样品中的生化结构和关键峰的能力。
方法:这篇综述全面探讨了FTIR光谱在医学研究中的多种应用,特别关注它在分析组织中的效用,细胞,和头发样本。各种来源,包括谷歌学者,PubMed,WorledCat和Scopus,被用来进行这篇全面的文献综述。
结果:最近的进展展示了FTIR光谱在阐明细胞和分子过程中的多功能性,促进疾病诊断,并实现治疗监测。值得注意的是,FTIR光谱在临床评估中发现了重要的实用性,特别是在筛选假药方面,由于其用户友好的操作和最小的样品制备要求。此外,海关官员可以利用这项技术对可疑样本进行初步分析。
结论:这篇综述旨在弥合文献中的空白,并作为未来医学领域FTIR光谱学研究的宝贵资源。此外,它介绍了FTIR光谱和光谱数据解释的基本概念,强调其作为使用中红外(MIR)辐射进行分子分析的工具的实用性。
BACKGROUND: Fourier Transform Infrared (FTIR) spectroscopy has emerged as a powerful analytical tool in medical research, offering non-invasive and precise examination of the molecular composition of biological samples. The primary objective of this review is to underscore the benefits of FTIR spectroscopy in medicinal research, emphasizing its ability to delineate molecular fingerprints and assist in the identification of biochemical structures and key peaks in biological samples.
METHODS: This review comprehensively explores the diverse applications of FTIR spectroscopy in medical investigations, with a specific focus on its utility in analyzing tissue, cells, and hair samples. Various sources, including Google Scholar, PubMed, WorledCat and Scopus, were utilized to conduct this comprehensive literature review.
RESULTS: Recent advancements showcase the versatility of FTIR spectroscopy in elucidating cellular and molecular processes, facilitating disease diagnostics, and enabling treatment monitoring. Notably, FTIR spectroscopy has found significant utility in clinical assessment, particularly in screening counterfeit medicines, owing to its user-friendly operation and minimal sample preparation requirements. Furthermore, customs officials can leverage this technique for preliminary analysis of suspicious samples.
CONCLUSIONS: This review aims to bridge a gap in the literature and serve as a valuable resource for future research endeavors in FTIR spectroscopy within the medical domain. Additionally, it presents fundamental concepts of FTIR spectroscopy and spectral data interpretation, highlighting its utility as a tool for molecular analysis using Mid-Infrared (MIR) radiation.