PDF(Pubmed)
Abstract：
The lateral root angle or gravitropic set-point angle (GSA) is an important trait for root system architecture (RSA) that determines the radial expansion of the root system. The GSA therefore plays a crucial role for the ability of plants to access nutrients and water in the soil. Only a few regulatory pathways and mechanisms that determine GSA are known. These mostly relate to auxin and cytokinin pathways. Here, we report the identification of a small molecule, mebendazole (MBZ), that modulates GSA in Arabidopsis thaliana roots and acts via the activation of ethylene signaling. MBZ directly acts on the serine/threonine protein kinase CTR1, which is a negative regulator of ethylene signaling. Our study not only shows that the ethylene signaling pathway is essential for GSA regulation but also identifies a small molecular modulator of RSA that acts downstream of ethylene receptors and that directly activates ethylene signaling.
摘要：
侧根角或重力设定点角（GSA）是根系结构（RSA）的重要特征，它决定了根系的径向扩张。因此，GSA对于植物获取土壤中的养分和水的能力起着至关重要的作用。仅已知确定GSA的少数调节途径和机制。这些主要涉及生长素和细胞分裂素途径。这里,我们报告了一种小分子的鉴定，甲苯咪唑（MBZ），它调节拟南芥根中的GSA，并通过激活乙烯信号发挥作用。MBZ直接作用于丝氨酸/苏氨酸蛋白激酶CTR1，它是乙烯信号传导的负调节剂。我们的研究不仅表明乙烯信号通路对于GSA调节至关重要，而且还鉴定了RSA的小分子调节剂，该调节剂作用于乙烯受体的下游并直接激活乙烯信号。
