PDF(Pubmed)
Abstract：
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus, leading to visual impairment if left untreated. This review discusses the use of optical coherence tomography angiography (OCTA) as a diagnostic tool for the early detection and management of DR. OCTA is a fast, non-invasive, non-contact test that enables the detailed visualisation of the macular microvasculature in different plexuses. OCTA offers several advantages over fundus fluorescein angiography (FFA), notably offering quantitative data. OCTA is not without limitations, including the requirement for careful interpretation of artefacts and the limited region of interest that can be captured currently. We explore how OCTA has been instrumental in detecting early microvascular changes that precede clinical signs of DR. We also discuss the application of OCTA in the diagnosis and management of various stages of DR, including non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), diabetic macular oedema (DMO), diabetic macular ischaemia (DMI), and pre-diabetes. Finally, we discuss the future role of OCTA and how it may be used to enhance the clinical outcomes of DR.
摘要：
糖尿病视网膜病变（DR）是糖尿病最常见的微血管并发症，如果不及时治疗会导致视力障碍。本文讨论了使用光学相干断层扫描血管造影（OCTA）作为早期发现和管理DR的诊断工具。OCTA是一个快速的，非侵入性，非接触测试，使黄斑微血管在不同的丛详细可视化。OCTA比荧光素眼底血管造影术（FFA）有几个优点，特别是提供定量数据。OCTA并非没有限制，包括仔细解释文物的要求以及目前可以捕获的有限感兴趣区域。我们探讨了OCTA如何在检测DR临床体征之前的早期微血管变化中发挥作用。我们还讨论了OCTA在DR各个阶段的诊断和管理中的应用。包括非增生性糖尿病视网膜病变（NPDR），增殖性糖尿病视网膜病变（PDR），糖尿病性黄斑水肿（DMO），糖尿病性黄斑缺血和糖尿病前期。最后,我们讨论了OCTA的未来作用以及它如何用于提高DR的临床结局。
