Abstract：
Protein-carbohydrate interactions are involved in several cellular and biological functions. Integrating structure and function of carbohydrate-binding proteins with disease-causing mutations help to understand the molecular basis of diseases. Although databases are available for protein-carbohydrate complexes based on structure, binding affinity and function, no specific database for mutations in human carbohydrate-binding proteins is reported in the literature. We have developed a novel database, CarbDisMut, a comprehensive integrated resource for disease-causing mutations with sequence and structural features. It has 1.17 million disease-associated mutations and 38,636 neutral mutations from 7,187 human carbohydrate-binding proteins. The database is freely available at https://web.iitm.ac.in/bioinfo2/carbdismut. The web-site is implemented using HTML, PHP and JavaScript and supports recent versions of all major browsers, such as Firefox, Chrome and Opera.
摘要：
蛋白质-碳水化合物相互作用涉及几种细胞和生物学功能。整合碳水化合物结合蛋白的结构和功能与致病突变有助于了解疾病的分子基础。尽管数据库可用于基于结构的蛋白质-碳水化合物复合物，结合亲和力和功能，文献中没有报道人类碳水化合物结合蛋白突变的特异性数据库.我们开发了一个新的数据库，CarbDisMut,具有序列和结构特征的致病突变的综合资源。它具有117万个疾病相关突变和来自7187个人类碳水化合物结合蛋白的38,636个中性突变。该数据库可在https://web上免费获得。iitm.AC.in/bioinfo2/carbismut.该网站使用HTML实现，PHP和JavaScript，并支持所有主要浏览器的最新版本，比如Firefox,Chrome和Opera
