%0 Journal Article
%T CarbDisMut: database on neutral and disease-causing mutations in human carbohydrate-binding proteins.
%A Shanmugam NRS
%A Kulandaisamy A
%A Veluraja K
%A Gromiha MM
%J Glycobiology
%V 34
%N 4
%D 2024 04 10
%M 38335248
%F 5.954
%R 10.1093/glycob/cwae011
%X Protein-carbohydrate interactions are involved in several cellular and biological functions. Integrating structure and function of carbohydrate-binding proteins with disease-causing mutations help to understand the molecular basis of diseases. Although databases are available for protein-carbohydrate complexes based on structure, binding affinity and function, no specific database for mutations in human carbohydrate-binding proteins is reported in the literature. We have developed a novel database, CarbDisMut, a comprehensive integrated resource for disease-causing mutations with sequence and structural features. It has 1.17 million disease-associated mutations and 38,636 neutral mutations from 7,187 human carbohydrate-binding proteins. The database is freely available at https://web.iitm.ac.in/bioinfo2/carbdismut. The web-site is implemented using HTML, PHP and JavaScript and supports recent versions of all major browsers, such as Firefox, Chrome and Opera.