Abstract：
As the number of adults aged over 40 with obesity increases dramatically, intermittent fasting interventions (IF) may help them to lose fat and weight. This systematic review investigated the most recent research on the effects of intermittent fasting and a regular diet on body composition and lipids in adults aged over 40 with obesity without the metabolic disease.
Randomized controlled trials (RCTs) on IF on adults aged over 40 with obesity were retrieved from PubMed, Web of Science, EBSCO, China Knowledge Network (CNKI), VIP database, Wanfang database with the experimental group using IF and the control group using a regular diet. Revman was used for meta-analysis. Effect sizes are expressed as weighted mean differences (WMD) and 95% confidence intervals (CI).
A total of 9 articles of randomised controlled trials that met the requirements were screened for inclusion. Studies typically lasted 2-6 weeks. The experimental population was aged 42-66 years, with a BMI range of 25.7-35 kg/m2.
A total of 9 RCTs were included. meta-analysis showed that body weight (MD: -2.05 kg; 95% CI (-3.84, -0.27); p = 0.02), BMI (MD: -0.73 kg/m2; 95% CI (-1.05, -0.41); p < 0.001), fat mass (MD: -2.14 kg; 95% CI (-3.81, 0.47); p = 0.01), and TG (MD = -0.32 mmol/L, 95% CI (-0.50, -0.15, p < 0.001) were significantly lower in the experimental group than in the control group. No significant reduction in lean body mass (MD: -0.31 kg; 95% CI (-0.96, 0.34); p = 0.35).
IF had a reduction in body weight, BMI, fat mass, and TG in adults aged over 40 with obesity without metabolic disease compared to RD, and IF did not cause a significant decrease in lean body mass, which suggests healthy and effective fat loss. However, more long-term and high-quality trials are needed to reach definitive conclusions.
Randomized controlled trials (RCTs) on IF on adults aged over 40 with obesity were retrieved from PubMed, Web of Science, EBSCO, China Knowledge Network (CNKI), VIP database, Wanfang database with the experimental group using IF and the control group using a regular diet. Revman was used for meta-analysis. Effect sizes are expressed as weighted mean differences (WMD) and 95% confidence intervals (CI).
A total of 9 articles of randomised controlled trials that met the requirements were screened for inclusion. Studies typically lasted 2-6 weeks. The experimental population was aged 42-66 years, with a BMI range of 25.7-35 kg/m2.
A total of 9 RCTs were included. meta-analysis showed that body weight (MD: -2.05 kg; 95% CI (-3.84, -0.27); p = 0.02), BMI (MD: -0.73 kg/m2; 95% CI (-1.05, -0.41); p < 0.001), fat mass (MD: -2.14 kg; 95% CI (-3.81, 0.47); p = 0.01), and TG (MD = -0.32 mmol/L, 95% CI (-0.50, -0.15, p < 0.001) were significantly lower in the experimental group than in the control group. No significant reduction in lean body mass (MD: -0.31 kg; 95% CI (-0.96, 0.34); p = 0.35).
IF had a reduction in body weight, BMI, fat mass, and TG in adults aged over 40 with obesity without metabolic disease compared to RD, and IF did not cause a significant decrease in lean body mass, which suggests healthy and effective fat loss. However, more long-term and high-quality trials are needed to reach definitive conclusions.
摘要：
目标：随着40岁以上肥胖的成年人数量急剧增加，间歇性禁食干预措施（IF）可能有助于他们减轻脂肪和体重。这项系统评价调查了有关间歇性禁食和定期饮食对40岁以上肥胖而没有代谢性疾病的成年人的身体成分和脂质的影响的最新研究。
方法：从PubMed检索有关40岁以上肥胖成年人IF的随机对照试验（RCT），WebofScience,EBSCO,中国知网(CNKI),VIP数据库,万方数据库中实验组使用IF，对照组使用常规饮食。Revman用于荟萃分析。效应大小表示为加权平均差(WMD)和95%置信区间(CI)。
方法：共筛选9篇符合要求的随机对照试验纳入。研究通常持续2-6周。实验人群年龄为42-66岁,BMI范围为25.7-35kg/m2。
结果：共纳入9项随机对照试验。荟萃分析显示体重（MD：-2.05kg；95％CI（-3.84，-0.27）；p=0.02），BMI（MD：-0.73kg/m2；95％CI（-1.05，-0.41）；p<0.001），脂肪量（MD：-2.14kg；95%CI（-3.81，0.47）；p=0.01），和TG（MD=-0.32mmol/L，试验组95%CI(-0.50,-0.15,p<0.001)显著低于对照组。瘦体重没有显著降低(MD:-0.31kg;95%CI(-0.96,0.34);p=0.35)。
结论：如果体重减轻，BMI,脂肪量,与RD相比，40岁以上肥胖无代谢性疾病的成年人的TG，如果没有引起瘦体重的显著下降，这表明健康和有效的脂肪损失。然而,需要更多长期和高质量的试验来得出明确的结论.
方法：从PubMed检索有关40岁以上肥胖成年人IF的随机对照试验（RCT），WebofScience,EBSCO,中国知网(CNKI),VIP数据库,万方数据库中实验组使用IF，对照组使用常规饮食。Revman用于荟萃分析。效应大小表示为加权平均差(WMD)和95%置信区间(CI)。
方法：共筛选9篇符合要求的随机对照试验纳入。研究通常持续2-6周。实验人群年龄为42-66岁,BMI范围为25.7-35kg/m2。
结果：共纳入9项随机对照试验。荟萃分析显示体重（MD：-2.05kg；95％CI（-3.84，-0.27）；p=0.02），BMI（MD：-0.73kg/m2；95％CI（-1.05，-0.41）；p<0.001），脂肪量（MD：-2.14kg；95%CI（-3.81，0.47）；p=0.01），和TG（MD=-0.32mmol/L，试验组95%CI(-0.50,-0.15,p<0.001)显著低于对照组。瘦体重没有显著降低(MD:-0.31kg;95%CI(-0.96,0.34);p=0.35)。
结论：如果体重减轻，BMI,脂肪量,与RD相比，40岁以上肥胖无代谢性疾病的成年人的TG，如果没有引起瘦体重的显著下降，这表明健康和有效的脂肪损失。然而,需要更多长期和高质量的试验来得出明确的结论.
