PDF(Pubmed)
Abstract：
BACKGROUND: Population-wide surveys and large-scale investigations highlighted the presence of cognitive deficits in the acute and postacute stages of severe COVID-19; a few studies documented their occurrence in cases without prior or COVID-19-related brain damage. The evolution of cognitive deficits in the latter population and their relationship to the post-COVID-19 fatigue syndrome are poorly understood.
METHODS: We report the outcome at 12 months after severe COVID-19 involving an intensive care unit stay and mechanical ventilation in six (five Caucasian and one Asian) patients (age range: 53-71 years, mean age 61.7 ± 6.5 years) without history of prior brain dysfunction and without stroke and/or cardiac arrest during or after COVID-19. All patients reported pervading mental and physical fatigue as well as numerous multidomain complaints, which impacted everyday life. Individual patients described mental fatigability, apathy, and/or anxiety. Standardized neuropsychological tests revealed isolated symptoms of cognitive dysfunction or performance at the lower limit of the norm in the attentional, executive, and/or working memory domains in four of the six patients. Somatic scales documented dyspnoea, muscle weakness, olfactory disorder, and/or minor sleep problems in some, but not all, patients.
CONCLUSIONS: Fatigue, fatigability, multidomain complaints, cognitive difficulties, or dysfunction, as well as isolated neurobehavioral and/or psychiatric and/or somatic symptoms, tend to occur in the aftermath of severe COVID-19 and persist at 12 months, even in the absence of prior and/or COVID-19-related brain damage. This clinical situation, which impacts everyday life, calls for a detailed investigation of patients\' complaints, its neural underpinning, and an elaboration of specific rehabilitation programs.
METHODS: We report the outcome at 12 months after severe COVID-19 involving an intensive care unit stay and mechanical ventilation in six (five Caucasian and one Asian) patients (age range: 53-71 years, mean age 61.7 ± 6.5 years) without history of prior brain dysfunction and without stroke and/or cardiac arrest during or after COVID-19. All patients reported pervading mental and physical fatigue as well as numerous multidomain complaints, which impacted everyday life. Individual patients described mental fatigability, apathy, and/or anxiety. Standardized neuropsychological tests revealed isolated symptoms of cognitive dysfunction or performance at the lower limit of the norm in the attentional, executive, and/or working memory domains in four of the six patients. Somatic scales documented dyspnoea, muscle weakness, olfactory disorder, and/or minor sleep problems in some, but not all, patients.
CONCLUSIONS: Fatigue, fatigability, multidomain complaints, cognitive difficulties, or dysfunction, as well as isolated neurobehavioral and/or psychiatric and/or somatic symptoms, tend to occur in the aftermath of severe COVID-19 and persist at 12 months, even in the absence of prior and/or COVID-19-related brain damage. This clinical situation, which impacts everyday life, calls for a detailed investigation of patients\' complaints, its neural underpinning, and an elaboration of specific rehabilitation programs.
摘要：
背景：全人群调查和大规模调查强调了严重COVID-19急性期和急性期存在认知缺陷；一些研究记录了在没有先前或COVID-19相关脑损伤的病例中发生认知缺陷。后者人群中认知缺陷的演变及其与COVID-19后疲劳综合征的关系知之甚少。
方法：我们报告了6名（5名白种人和1名亚洲人）患者（年龄范围：53-71岁，严重COVID-19包括重症监护病房和机械通气的12个月后的结果，平均年龄61.7±6.5岁)，在COVID-19期间或之后没有脑功能障碍病史，也没有中风和/或心脏骤停。所有患者都报告了普遍的精神和身体疲劳以及许多多领域的投诉，影响了日常生活。个别患者描述了精神疲劳，冷漠,和/或焦虑。标准化的神经心理学测试显示，在注意力正常的下限，认知功能障碍或表现的孤立症状，Executive,和/或工作记忆领域的六名患者。体细胞量表记录了呼吸困难，肌肉无力,嗅觉障碍,和/或一些轻微的睡眠问题，但不是全部,患者。
结论：疲劳，可疲劳性,多领域投诉，认知困难，或功能障碍，以及孤立的神经行为和/或精神和/或躯体症状，往往发生在严重的COVID-19之后，并在12个月时持续存在，即使没有先前和/或COVID-19相关的脑损伤。这种临床情况，影响日常生活，呼吁对患者的投诉进行详细调查，它的神经支撑，并制定了具体的康复计划。
方法：我们报告了6名（5名白种人和1名亚洲人）患者（年龄范围：53-71岁，严重COVID-19包括重症监护病房和机械通气的12个月后的结果，平均年龄61.7±6.5岁)，在COVID-19期间或之后没有脑功能障碍病史，也没有中风和/或心脏骤停。所有患者都报告了普遍的精神和身体疲劳以及许多多领域的投诉，影响了日常生活。个别患者描述了精神疲劳，冷漠,和/或焦虑。标准化的神经心理学测试显示，在注意力正常的下限，认知功能障碍或表现的孤立症状，Executive,和/或工作记忆领域的六名患者。体细胞量表记录了呼吸困难，肌肉无力,嗅觉障碍,和/或一些轻微的睡眠问题，但不是全部,患者。
结论：疲劳，可疲劳性,多领域投诉，认知困难，或功能障碍，以及孤立的神经行为和/或精神和/或躯体症状，往往发生在严重的COVID-19之后，并在12个月时持续存在，即使没有先前和/或COVID-19相关的脑损伤。这种临床情况，影响日常生活，呼吁对患者的投诉进行详细调查，它的神经支撑，并制定了具体的康复计划。
