METHODS: We report the outcome at 12 months after severe COVID-19 involving an intensive care unit stay and mechanical ventilation in six (five Caucasian and one Asian) patients (age range: 53-71 years, mean age 61.7 ± 6.5 years) without history of prior brain dysfunction and without stroke and/or cardiac arrest during or after COVID-19. All patients reported pervading mental and physical fatigue as well as numerous multidomain complaints, which impacted everyday life. Individual patients described mental fatigability, apathy, and/or anxiety. Standardized neuropsychological tests revealed isolated symptoms of cognitive dysfunction or performance at the lower limit of the norm in the attentional, executive, and/or working memory domains in four of the six patients. Somatic scales documented dyspnoea, muscle weakness, olfactory disorder, and/or minor sleep problems in some, but not all, patients.
CONCLUSIONS: Fatigue, fatigability, multidomain complaints, cognitive difficulties, or dysfunction, as well as isolated neurobehavioral and/or psychiatric and/or somatic symptoms, tend to occur in the aftermath of severe COVID-19 and persist at 12 months, even in the absence of prior and/or COVID-19-related brain damage. This clinical situation, which impacts everyday life, calls for a detailed investigation of patients\' complaints, its neural underpinning, and an elaboration of specific rehabilitation programs.
方法:我们报告了6名(5名白种人和1名亚洲人)患者(年龄范围:53-71岁,严重COVID-19包括重症监护病房和机械通气的12个月后的结果,平均年龄61.7±6.5岁),在COVID-19期间或之后没有脑功能障碍病史,也没有中风和/或心脏骤停。所有患者都报告了普遍的精神和身体疲劳以及许多多领域的投诉,影响了日常生活。个别患者描述了精神疲劳,冷漠,和/或焦虑。标准化的神经心理学测试显示,在注意力正常的下限,认知功能障碍或表现的孤立症状,Executive,和/或工作记忆领域的六名患者。体细胞量表记录了呼吸困难,肌肉无力,嗅觉障碍,和/或一些轻微的睡眠问题,但不是全部,患者。
结论:疲劳,可疲劳性,多领域投诉,认知困难,或功能障碍,以及孤立的神经行为和/或精神和/或躯体症状,往往发生在严重的COVID-19之后,并在12个月时持续存在,即使没有先前和/或COVID-19相关的脑损伤。这种临床情况,影响日常生活,呼吁对患者的投诉进行详细调查,它的神经支撑,并制定了具体的康复计划。