PDF(Pubmed)
Abstract：
Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3-6), together with two new chromone derivatives, penithochromones X and Y (7 and 8). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis. Sclerotioramine (3) showed significant antibacterial activities against B. subtilis and S. dysentery, and it also showed most potent anti-plant pathogenic fungi activities against P. theae, C. miyabeanus, and E. turcicum.
摘要：
青霉的化学研究。GDGJ-N37，一种山豆根相关真菌，产生了两个新的氮杂吡酮衍生物，N-异淀粉硬核胺（1）和7-甲氧基-N-异淀粉硬核胺（2），和四个已知的氮杂菲酮（3-6），以及两种新的色酮衍生物，X和Y(7和8)。根据光谱数据阐明了它们的结构，CD光谱,半合成。硬核胺(3)对枯草芽孢杆菌和痢疾有显著的抗菌活性,它还显示出最有效的抗植物病原真菌活性。C.miyabeanus,和E.turcicum.
