%0 Journal Article
%T Isolation and Characterization of Antimicrobial Metabolites from the Sophora tonkinensis-Associated Fungus Penicillium sp. GDGJ-N37.
%A Huang L
%A Li Y
%A Pang J
%A Lv L
%A Zhou J
%A Liang L
%A He X
%A Li J
%A Xu W
%A Yang R
%J Molecules
%V 29
%N 2
%D 2024 Jan 10
%M 38257261
%F 4.927
%R 10.3390/molecules29020348
%X Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3-6), together with two new chromone derivatives, penithochromones X and Y (7 and 8). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis. Sclerotioramine (3) showed significant antibacterial activities against B. subtilis and S. dysentery, and it also showed most potent anti-plant pathogenic fungi activities against P. theae, C. miyabeanus, and E. turcicum.