PDF(Pubmed)
Abstract：
This narrative review critically examines the current research on the health implications of whey protein (WP) supplementation, with a focus on potential risks and adverse effects. WP, commonly consumed for muscle building and weight loss, has been associated with various health concerns. Our comprehensive analysis involved a thorough search of multiple databases, resulting in the inclusion of 21 preclinical and human studies that collectively offer a detailed overview of WP\'s health impacts. The review reveals significant findings, such as WP\'s potential link to liver and kidney damage, alterations in gut microbiota, increased acne incidence, impacts on bone mass, and emotional and behavioural changes. These findings underscore the complexity of WP\'s effects on human health, indicating both beneficial and detrimental outcomes in relation to different posologies in a variety of settings. Our study suggests caution for the protein intake in situations of hepatic and renal compromised functions, as well as in acne susceptibility, while possible beneficial effects can be achieved for the intestinal microbiota, humoral and behavioural level, and finally bone and muscle mass in elderly. We emphasizes the importance of balanced WP consumption and call for more in-depth research to understand its long-term health effects. Health professionals and individuals considering WP supplementation should be aware of these potential risks and approach its use with informed caution.
摘要：
这篇叙述性综述严格审查了当前关于补充乳清蛋白（WP）对健康的影响的研究，关注潜在风险和不利影响。WP,通常用于肌肉锻炼和减肥，与各种健康问题有关。我们的全面分析涉及对多个数据库的彻底搜索，结果纳入了21项临床前和人体研究，这些研究共同提供了WP\的健康影响的详细概述。审查揭示了重要的发现，例如WP与肝肾损害的潜在联系，肠道微生物群的改变，痤疮发病率增加，对骨量的影响，以及情绪和行为的变化。这些发现强调了WP对人类健康影响的复杂性，表明在各种设置中与不同的姿势有关的有益和有害结果。我们的研究表明，在肝肾功能受损的情况下，蛋白质摄入应谨慎，以及在痤疮易感性，虽然可能的有益效果可以实现对肠道微生物群，体液和行为水平，最后是老年人的骨骼和肌肉质量。我们强调平衡WP消费的重要性，并呼吁进行更深入的研究以了解其长期健康影响。考虑补充WP的卫生专业人员和个人应意识到这些潜在风险，并谨慎使用。
