心脏代谢疾病是全球领先的健康挑战。它们的发病率以及进展受到饮食的强烈影响。平菇(P.平菇),富含功能成分的可食用牡蛎蘑菇(例如,β-葡聚糖),可以改善葡萄糖和脂质代谢,血压,体重和食欲的感觉。因此,本系统综述旨在从临床试验中概述平菇摄入对心脏代谢参数的影响,考虑到偏见风险(RoB)。考虑到系统审查和荟萃分析(PRISMA)指南的首选报告项目,对相关研究进行了详细调查。Cochrane协作的工具用于评估RoB。总的来说,8项试验包括观察到的平菇摄入对葡萄糖代谢(降低空腹和/或餐后2小时葡萄糖)和脂质(降低总胆固醇,LDL-胆固醇和/或甘油三酯),一些人发现血压下降了。相比之下,体重没有变化。没有评估食欲感觉。在大多数研究中,由于方法学缺陷和/或报告不足,RoB较高或不清楚。因此,平菇的摄入可以改善心脏代谢健康,但这方面的证据不足.因此,需要进一步的临床试验和适当的研究设计来验证这些建议.
Cardiometabolic diseases are a leading global health challenge. Their incidence as well as progression is strongly affected by diet. Consumption of Pleurotus ostreatus (P. ostreatus), an edible oyster mushroom rich in functional ingredients (e.g., β-glucans), may improve glucose and lipid metabolism, blood pressure, body weight and appetite sensations. Hence, this systematic review aimed to provide an overview on the effects of P. ostreatus intake on cardiometabolic parameters from clinical trials, taking into account risk of bias (RoB). Relevant studies were investigated for details with consideration of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The Cochrane Collaboration\'s tool was used to assess the RoB. In total, eight trials included observed beneficial effects of P. ostreatus intake on glucose metabolism (reduction in fasting and/or 2 h postprandial glucose) and lipids (decrease in total cholesterol, LDL-cholesterol and/or triglycerides), and some found a reduction in blood pressure. In contrast, body weight did not change. Appetite sensations were not assessed. In most studies, the RoB was high or unclear due to methodological weaknesses and/or inadequate reporting. Thus, P. ostreatus intake may improve cardiometabolic health, but evidence for this is low. Hence, further clinical trials with an adequate study design are warranted to validate these suggestions.