Abstract：
In a remarkable recent study, Miao et al. reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs). The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and significantly advance our understanding of this inflammatory cell death mechanism.
摘要：
在最近一项引人注目的研究中，苗等人。揭示gasderminDN末端（GSDMD-NT）通过在线粒体内膜和外膜（OMM）中形成孔来刺激线粒体损伤。作者强调了线粒体心磷脂在GSDMD-NT作用中的关键作用，并大大推进了我们对这种炎性细胞死亡机制的理解。
